Surface tyre imprints caused by a motorcycle collision rather than by being run over.

Tyre imprints on the skin are usually considered to be the result of being run over by a motor vehicle. This article reports a traffic accident in which tyre marks on the victim's skin were caused by a collision rather than by being run over. The mechanism of the injury in this case is analysed and discussed. A 23-year-old male drove a motorcycle while under the influence of alcohol and collided with a sign pillar on the side of the road. Both the victim and the motorcycle careened into the bottom of a tractor-trailer. No witnesses or surveillance videos could confirm the process of the accident. Because tyre imprints were found on the victim's skin, traffic police believed that he had been run over during the accident. However, forensic autopsy and analysis of the accident process revealed that the true cause of the imprints was a collision between the victim's body and a tyre.

AUF1 modulates TGF-ß signal in renal tubular epithelial cells via post-transcriptional regulation of Nedd4L expression.

Posttranscriptional regulation process plays important roles in renal disease pathogenesis. AU-rich element RNA-binding protein (AUF1) interacts with and destabilizes mRNAs containing AU-rich elements (AREs) in their 3'UTR. The current study demonstrated that AUF1 was increased in unilateral ureteral obstruction (UUO) animal models. While proliferation and migration of HK2 cells was unaltered by AUF1 downregulation under normal condition, proliferative inhibition and migratory promotion mediated by TGF-ß was significantly compromised. Mechanically, AUF1 downregulation decreased phosphorylated Smad2/3 via increasing their E3 ligase Nedd4L at the posttranscriptional level. In addition, the current study identified Nedd4L as a previously unreported target of AUF1. AUF1 regulates Nedd4L expression at the posttranscriptional level by interaction with AREs in the 3'UTR of the Nedd4L mRNA. Collectively, the current study indicates that AUF1 might be a potential player in renal tubulointerstitial fibrosis through modulation of TGF-ß signal transduction via posttranscriptional regulation of Nedd4L.

[Impact of tillage and nutrient management practices on the spring weed community in a winter wheat-summer maize rotation farmland]. / è€•ä½œå’Œå »åˆ†ç®¡ç†æ–¹å¼å¯¹å†¬å°éº¦-夏玉米轮作农田春季杂草群落的影响.

Conservation tillage and the weed diversity are two hot issues in the modern ecological agriculture. Although it is known that the diversity of weed would increase slightly in the farmland under conservation tillage, the interaction effects between the tillage and the nutrient management on the weed community are not clear. In this study, one wheat-maize rotation field located in Ji'nan, Shandong Province, was selected as the studying site. Different tillage methods (no-tillage, deep subsoiling, rotary tillage, deep tillage) and different nutrient managements (farmers routine, 480 kg N hm-2 per year; high production and efficiency, 360 kg N hm-2 per year; optimal management, 300 kg N hm-2 per year) were carried out for 3 years. The characteristics of the spring weed communities under different managements were investigated and compared. The results showed that there were 15 species in the spring weed communities in the test filed and Digitaria sanguinalis and Echinochloa crusgalli were the dominant species. The plots under no-tillage or deep subsoiling had higher weed densities compared with those under the deep tillage or rotary tillage. In terms of the effect of tillage on the weed community diversity, both species richness index and species evenness index were lowest but the community dominance index was highest in the plots under deep tillage. In terms of the effect of the nutrient management, with the increase of fertilizer application, both species richness and evenness index increased under the different tillage methods. The community dominance increased with the increasing fertilizer application under deep tillage or rotary tillage and vice versa under no-tillage, deep subsoiling. In terms of weed biomass, the plots under no-tillage or deep subsoiling had significantly higher weed biomass than those under the other two tillage methods. The plots under routine nutrient management had higher weed biomass than those under the other two nutrient managements. Among all these treatments, the plots under the combination treatment of no-tillage and routine nutrient management had the highest weed biomass. According to these results, it was implied that no-tillage and fertilization would improve species richness index, species evenness index, and the productivity of spring weed community in the wheat-maize farmland.