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1.
Ying Yong Sheng Tai Xue Bao ; 25(9): 2665-70, 2014 Sep.
Article in Chinese | MEDLINE | ID: mdl-25757320

ABSTRACT

In order to gain better understanding of the oviposition preference of Grapholitha molesta, we studied the ovipositional preference on different host fruit leaves, different parts of peach bran- ches and different varieties of peach in simulated outdoor conditions. The adult ovipositional preference on the host fruit leaves was in descending order, i. e. peach > cherry > apple > plum > pear > crabapple > apricot, and 33.5% of eggs were laid on the peach leaves with the average number of egg on one peach leaf being 8.3. There were differences in egg distribution on both sides of the leaves in different hosts. The number of egg laid on the positive surface was more than on the reverse surface of apple and crabapple leaves, and vice versus for peach, plum, pear and apricot leaves, and 3.3 times more eggs were laid on the reverse surface of peach leaves than on the positive surface. The egg distribution had no significant difference on both sides of cherry leaves. The adult ovipositional preference on peach branches was in descending order of leaf > stipule > petiole > branch. The leaves were the major ovipositonal places with 88.7% of total eggs on. 72.5% of eggs were laid on the 10 leaves near the top unexpanded leaflets, and the maximum number was on the 3rd leaf accounting for 9.3%, while only 1.1% of eggs were laid on the peach leaves after 25th. The ovipositional preference on different peach fruits was in descending order of nectarine > flat peach > prunus persica. The density and characteristics of the hair on host fruits and leaves were the primary factors affecting the ovipositional preference.


Subject(s)
Lepidoptera/physiology , Oviposition , Animals , Female , Malus , Plant Leaves , Prunus
2.
J Agric Food Chem ; 61(31): 7599-605, 2013 Aug 07.
Article in English | MEDLINE | ID: mdl-23855516

ABSTRACT

The regulatory effects of haw pectin pentaoligosaccharide (HPPS) on fatty acid oxidation-related enzyme activities and mRNA levels were investigated in the liver of high fat diet induced hyperlipidemic mice. Results showed that HPPS (150 mg/kg for 10 weeks) significantly suppresses weight gain (32.3 ± 0.26 and 21.1 ± 0.14 g for high-fat diet and HPPS groups, respectively), decreases serum triacylglycerol levels (1.64 ± 0.09 and 0.91 ± 0.02 mmol/L, respectively), and increases lipid excretion in feces (55.7 ± 0.38 and 106.4 ± 0.57 mg/g for total lipid, respectively), compared to high-fat diet as control. HPPS significantly increased the hepatic fatty acid oxidation-related enzyme activities of acyl-CoA oxidase, carnitine palmitoyltransferase I, 3-ketoacyl-CoA thiolase, and 2,4-dienoyl-CoA reductase by 53.8, 74.2, 47.1, and 24.2%, respectively. Meanwhile, the corresponding mRNAs were up-regulated by 89.6, 85.8, 82.9, and 30.9%, respectively. Moreover, HPPS was able to up-regulate the gene and protein expressions of peroxisome proliferator-activated receptor α. Results suggest that continuous HPPS ingestion may be used as dietary therapy to prevent obesity and cardiovascular diseases.


Subject(s)
Crataegus/chemistry , Fatty Acids/metabolism , Hyperlipidemias/drug therapy , Liver/enzymology , Oligosaccharides/administration & dosage , Pectins/administration & dosage , Plant Extracts/administration & dosage , Acyl-CoA Oxidase/metabolism , Animals , Carnitine O-Palmitoyltransferase/metabolism , Diet, High-Fat/adverse effects , Humans , Hyperlipidemias/enzymology , Hyperlipidemias/genetics , Hyperlipidemias/metabolism , Liver/drug effects , Liver/metabolism , Male , Mice , Oxidation-Reduction , Oxidoreductases/metabolism , Oxidoreductases Acting on CH-CH Group Donors/metabolism
4.
Hematol Oncol ; 29(4): 185-9, 2011 Dec.
Article in English | MEDLINE | ID: mdl-21692100

ABSTRACT

Recent studies have suggested that chromosomal aberrations of the MYC gene locus indicate an unfavorable prognosis in diffuse large B-cell lymphoma (DLBCL). However, there have been few reports on MYC translocation in Chinese patients. One hundred and six cases of DLBCLs were analyzed using interphase fluorescent in situ hybridization. Immunophenotyping analysis (CD20, CD3, CD10, Bcl-6, Mum-1) was also performed. MYC translocation was identified in 13 (12.3%) out of 106 cases. All MYC(+) DLBCLs showed a non-germinal center B-cell type. MYC(+) DLBCLs showed significantly poorer overall survival (OS) and progression-free survival, with a median OS and progression-free survival time of 4.7 and 3.2 months, respectively (p < 0.001). Multivariate analysis using a Cox proportional hazard model confirmed that MYC(+) (for OS, Hazards ratio 5.254; 95% CI, 2.354-11.723, p < 0.001) was the strongest independent predictor. DLBCL with MYC translocation is a subgroup of non-germinal center B-cell DLBCL with poor outcome. This may be a clinical characteristic that is specific to Chinese patients. Because only a few patients received rituximab, its usefulness could not be assessed. Future studies with larger numbers of patients are required.


Subject(s)
Genes, myc , Lymphoma, Large B-Cell, Diffuse/mortality , Translocation, Genetic , Aged , Aged, 80 and over , Female , Humans , Immunophenotyping , Kaplan-Meier Estimate , Lymphoma, Large B-Cell, Diffuse/diagnosis , Lymphoma, Large B-Cell, Diffuse/genetics , Male , Middle Aged , Prognosis
5.
Chin J Cancer Res ; 23(2): 160-4, 2011 Jun.
Article in English | MEDLINE | ID: mdl-23482616

ABSTRACT

OBJECTIVE: Recent studies have suggested that t(14;18) is present in a significant proportion of diffuse large B-cell lymphomas (DLBCLs). However, the prognostic significance of this translocation and its relationship with BCL-2 protein expression remains controversial. Our study aimed to investigate the predictive power of t(14;18) and BCL-2 protein expression in the prognosis of DLBCLs. METHODS: Biopsy specimens from 106 DLBCLs were analyzed using interphase fluorescence in situ hybridization (FISH). Immunophenotypic analysis of CD20, CD3, CD10, BCL-6, MUM1 and BCL-2 was performed by immunohistochemistry. SPSS 13.0 software was used for statistical analysis. RESULTS: The t(14;18) was identified in 27 of 106 cases (25.5%). The percentages of tumor cells expressing CD10, BCL-6, MUM1 and BCL-2 were 21.7%, 26.4%, 56.6% and 73.6%, respectively. The presence of this translocation was significantly correlated with the expression of CD10 and immunophenotypic subtype (p<0.001). No association was observed between BCL-2 protein expression and the presence of t(14;18). Multivariate analysis confirmed that both t(14;18) and BCL-2 expression were significantly associated with survival. Moreover, patients with t(14;18) had worse prognosis, compared with those with BCL-2 expression (for overall survival: hazard ratio, 4.235; 95%CI, 2.153-8.329, p<0.001 vs. hazard ration, 2.743; 95%CI, 1.262-5.962, p=0.011). CONCLUSIONS: The t(14;18) is a useful prognostic tool for the evaluation of DLBCL immunophenotype and prognosis. The prognosis of GCB (germinal centre-like B cell) DLBCL patients should be made with the consideration of the presence of this translocation, and the detection of t(14;18) should be included as a routine diagnostic test in these cases.

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