Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis.

Severe acute pancreatitis (SAP) is a common acute abdominal disease accompanied by systemic inflammatory response syndrome, which may be complicated by acute kidney injury (AKI). Isoacteoside (ISO) is the active ingredient of Monochasma savatieri Franch. ex Maxim and has been reported to have anti­inflammatory activities. The present study detected the effects of ISO on AKI induced by SAP in rat models, and the underlying mechanism. The optimum dose of ISO for treatment of AKI induced by SAP was determined. The serum levels of TNF­α and IL­6 were estimated using an ELISA. Kidney injury was evaluated by histopathological examination, and the expression levels of nitric oxide were also detected. The expression levels of Toll­like receptor 4 (TLR4) and NF­κB p65 were measured by immunohistochemistry and western blotting. The results revealed that ISO may serve a critical role in ameliorating AKI induced by SAP. These effects may be associated with the TLR4/NF­κB signaling pathway.

Quantum hyperentanglement and its applications in quantum information processing.

Hyperentanglement is a promising resource in quantum information processing with its high capacity character, defined as the entanglement in multiple degrees of freedom (DOFs) of a quantum system, such as polarization, spatial-mode, orbit-angular-momentum, time-bin and frequency DOFs of photons. Recently, hyperentanglement attracts much attention as all the multiple DOFs can be used to carry information in quantum information processing fully. In this review, we present an overview of the progress achieved so far in the field of hyperentanglement in photon systems and some of its important applications in quantum information processing, including hyperentanglement generation, complete hyperentangled-Bell-state analysis, hyperentanglement concentration, and hyperentanglement purification for high-capacity long-distance quantum communication. Also, a scheme for hyper-controlled-not gate is introduced for hyperparallel photonic quantum computation, which can perform two controlled-not gate operations on both the polarization and spatial-mode DOFs and depress the resources consumed and the photonic dissipation.

Complete hyperentangled Bell state analysis for polarization and time-bin hyperentanglement.

We present a complete hyperentangled Bell state analysis protocol for two-photon four-qubit states that are simultaneously entangled in the polarization and time-bin degrees of freedom. The 16 hyperentangled states can be unambiguously distinguished via two steps. In the first step, the polarization entangled state is distinguished deterministically and nondestructively with the help of the cross-Kerr nonlinearity. Then, in the second step, the time-bin state is analyzed with the aid of the polarization entanglement. We also discuss the applications of our protocol for quantum information processing. Compared with hyperentanglement in polarization and spatial-mode degrees of freedom, the polarization and time-bin hyperentangled states provide savings in quantum resources since there is no requirement for two spatial modes for each photon. This is the first complete hyperentangled Bell state analysis scheme for polarization and time-bin hyperentangled states, and it can provide new avenues for high-capacity, long-distance quantum communication.

Efficient hyperconcentration of nonlocal multipartite entanglement via the cross-Kerr nonlinearity.

We propose two schemes for concentration of hyperentanglement of nonlocal multipartite states which are simultaneously entangled in the polarization and spatial modes. One scheme uses an auxiliary single-photon state prepared according to the parameters of the less-entangled states. The other scheme uses two less-entangled states with unknown parameters to distill the maximal hyperentanglement. The procrustean concentration is realized by two parity check measurements in both the two degrees of freedom. Nondestructive quantum nondemolition detectors based on cross-Kerr nonlinearity are used to implement the parity check, which makes the unsuccessful instances reusable in the next concentration round. The success probabilities in both schemes can be made to approach unity by iteration. Moreover, in both schemes only one of the N parties has to perform the parity check measurements. Our schemes are efficient and useful for quantum information processing involving hyperentanglement.