ABSTRACT
The chemical constituents and pharmacological activities on the genus of Symplocos were reviewed. Their constituents mainly included triterpenes and triterpenoid saponins, flavonoids, iridoids, lignans, alkaloids, polysaccharides and ellagic acids. A number of species among them have been used as folk medicine for the treatment of fever, detoxifying, acesodyne and hemostasis.
Subject(s)
Drugs, Chinese Herbal/pharmacology , Flavonoids/isolation & purification , Magnoliopsida/chemistry , Plants, Medicinal/chemistry , Triterpenes/isolation & purification , Alkaloids/chemistry , Alkaloids/isolation & purification , Anti-HIV Agents/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Drugs, Chinese Herbal/chemistry , Drugs, Chinese Herbal/isolation & purification , Flavonoids/chemistry , Lignans/chemistry , Lignans/isolation & purification , Molecular Structure , Triterpenes/chemistryABSTRACT
A new triterpenoid, 2beta,3beta,19alpha,24-tetrahydroxy-23-norurs-12-en-28-oic acid (4), together with three known triterpenoids 3-oxo-19alpha,23,24-trihydroxyurs-12-en-28-oic acid (1), 2alpha,3beta,19alpha,23-tetrahydroxyurs-12-en-28-oic acid (2), 2alpha,3alpha,19alpha,23-tetrahydroxyurs-12-en-28-oic acid (3), was isolated from the roots of Symplocos chinensis. The new triterpenoid shows significant cytotoxic activity against B16 and BGC-823 cells.
