ABSTRACT
Acorssocheilus beijiangensis is an endemic south China stream-dwelling cyprinid species. Its complete mitochondrial genome is 16,596 bp in length, consisting of 13 protein-coding genes, 22 tRNA genes (ranging from 67 bp in tRNACys to 76 bp in tRNALeu and tRNALys ), two rRNA genes (959 bp in 12S rRNA and 1683 bp in 16S rRNA), and one control region (937 bp). Its overall base composition is A: 31.1%, C: 27.9%, G: 16.2%, and T: 124.8%. The complete mitogenome of the Chinese barred species of Cyprinidae could provide a basic data for further phylogenetics analysis.
ABSTRACT
<p><b>AIM</b>To observe redox modulation of ion channel in trigeminal ganglion neurons by oxidants and reducing agents.</p><p><b>METHODS</b>The effects of oxidants and reducing agents on maxi-conductance calcium-activated potassium channel in cultured rat trigeminal ganglion neurons by using whole-cell patch-clamp technique.</p><p><b>RESULTS</b>Methionine-specific oxidant chloramine-T (Ch-T) 1 mmol/L slightly increased the current amplitude and this enhancement did not antagonized by DTT. In contrast, cysteine-specific reagent 5, 5'-dithio-bis(2-nitrobenzoic acid) (DTNB) 500 micromol/L significantly decreased current amplitude of BK(Ca) channels. The effect was reversed by the reducing agent 2 mmol/L 1, 4-dithio-DL-threitol (DTT).</p><p><b>CONCLUSION</b>Reactive oxygen species were definitely involved in regulation of native neuronal function via redox modulation of BK(Ca) channels, which are suggested to play compensatory roles under oxidative stress-related conditions.</p>
