The dissemination of CMV in urine of different group from Guangxi and the relationship between CMV infection and renal disease / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>To detect Human Cytomegalovirus (HCMV) DNA in urine samples from the following groups: pregnant women, sick newborns, hospitalized nephropathy patients, renal transplant recipients and normal population. Preliminarily study the relationship of HCMV infection and renal disease.</p><p><b>METHODS</b>To detect HCMV DNA in morning urine samples by Real-time fluorescence quantitative PCR (FQ-PCR).</p><p><b>RESULTS</b>The positive rates of HCMV DNA in the urine of pregnant women,sick newborns, hospitalized nephropathy patients, renal transplant recipients and normal population are 8.18%, 3.45%, 18.54%, 25.42%, 0.56%.</p><p><b>CONCLUSION</b>The infection rates of HCMV in the urine of pregnant women and sick newborns are very high in Guangxi, it should take serious measures to prevent and control the situation. HCMV probably participate in the injury of kidney, and worsen the disease. It should be one of the causes of renal disease.</p>

The genetic relation of four ethnic populations in China's Guizhou is revealed by sequence variations of mtDNA D-loop / 中华医学遗传学杂志

<p><b>OBJECTIVE</b>Through maternal inheritance, to explore the genetic structures and relationships of Dong, Gelao, Tujia and Yi ethnic population in Guizhou of China.</p><p><b>METHODS</b>The mtDNA D-loop hypervariable segment I (HVS I ) in 108 samples of four ethnic populations were sequenced. Then, the nucleotide diversity was estimated and a phylogenetic tree was constructed by Neighbor-Joining method.</p><p><b>RESULTS</b>In the detected 497 bp fragments, 86 polymorphic sites were found, and 82 different haplotypes were identified. The phylogenetic tree of four ethnic populations showed: Yi, Tujia and Gelao clustered more closely than Dong did.</p><p><b>CONCLUSION</b>Yi and Tujia population are very closely related, the reason may be that they either originate from a common ancestry or frequently undergo the gene exchanges and admixtures. The genetic relationship between Tujia and Gelao population is nearer, perhaps because they have settled in the adjacent regions. Dong and Yi population show the farthest genetic relationship, this is probably due to their different historical origins and geographic segregation.</p>