ABSTRACT
Objective To analyze the global literature output and citation of publications pertaining to artemisinin (ART) resistance in Plasmodium falciparum from 2011 to 2021, so as to provide insights into researches on resistance of P. falciparum to ART. Methods The publications pertaining to ART resistance in P. falciparum were retrieved from the Science Citation Index Expanded (SCIE) database in Web of Science during the period from January 2011 through May 2022. The subject, journal, country, affiliation and author distributions and citations of publications were descriptively analyzed. Results A total of 1 640 publications pertaining to ART resistance in P. falciparum were retrieved in the SCIE database during the period from January 2011 through May 2022, and the number of publications appeared an overall tendency towards a rise during the study period. These articles were published in 343 journals, and the three most productive journals included Malaria Journal (341 publications, 20.79%), Antimicrobial Agents and Chemotherapy (141 publications, 8.60%), American Journal of Aropical Medicine and Hygiene (68 publications, 4.15%), with infectious diseases (565 publications, 34.45%), parasitology (531 publications, 32.38%), and tropical medicine (517 publications, 31.54%) as the predominant subject. The three most productive countries included the United States of America (627 publications, 38.23%), United Kingdom (395 publications, 24.08%), and Thailand (294 publications, 17.94%), with total citations of 25 280, 18 622 and 15 474, respectively, and the most productive countries included Mahidol University (Thailand), Oxford University (England) and London University (England), with 234, 220 publications and 142 publications and 15 058, 15 421 citations and 6 191 citations, respectively. The three most productive authors were all from Mahidol University, with 85, 77 and 63 publications, respectively; and among the three most cited authors, two were from Mahidol University, Thailand, with 8 623 and 7 961 total citations, and one from National Institutes of Health, the United States of America, with 6 267 total citations. A total of 138 articles were published by Chinese scientists, with 3 434 total citations, and National Institute of Parasitic Diseases of Chinese Center for the Diseases Control and Prevention was the most productive Chinese institution, with 35 publications, 1 165 total citations and 33.29 citations per publication. Conclusions The literature output of ART resistance in P. falciparum was relatively high in the United States of America, Europe, and Southeast Asian countries during the period from 2011 to 2021, with a relatively high academic impact. Publications in Malaria Journal and Antimicrobial Agents and Chemotherapy are recommended to be paid much attention by Chinese scientists to understand the latest advances and extend the research interests.
ABSTRACT
OBJECTIVE: To investigate the Toxoplasma gondii infection situation and relative factors in reproductive women in Shandong area, so as to provide the evidences for establishing strategies for reducing the birth defects and improving the quality of population. METHODS: A total of 5 386 reproductive women who visited hospitals at county and city levels in Shandong region from January 2013 to December 2015 were treated as the research objects, and their venous blood samples were collected to detect the antibodies (IgG and IgM) against T. Gondii in serum. Meanwhile, the related risk factors of T. gondii infection were surveyed by questionnaires. RESULTS: Among the 5 386 reproductive women, 623 ones were positive for IgG antibody and the positive rate was 11.56%, and 328 ones were positive for IgM antibody and the positive rate was 6.21%. The single factor analysis showed that the pregnant status (χ2 = 13.12, P < 0.01), whether the residences were in downtowns or counties (χ2 = 6.27, P < 0.05), whether having animal contact history (χ2 = 10.46, P < 0.01), and whether eating half-baked foods (χ2 = 21.19, P < 0.01) were related to T. gondii infection. CONCLUSIONS: The T. gondii infection rate of reproductive women in Shandong Province is high; the related risk factors include pregnant status, residence, degree of intimate contact with animal, and whether eating half-baked foods. It suggests that the detection of T. gondii infection and health education in reproductive women should be strengthened.
