[Cycloferon therapy of chronic gastroduodenitis in children].

The efficiency of immunomodulating therapy with cycloferon in children aged from 10 to 16 years with verified chronic gastroduodenitis was estimated. It was shown that the cycloferon treatment provided reliable increase of T- and B-cellular populations in mucous membranes of the stomach and duodenum, normalization of the number of CD8-lymphocytes, higher titers of IgG antibodies to herpes viruses 1 and 2. It also promoted reduction of inflammation in the mucous membranes along with reduction of the disease clinical signs.

[Effect of cycloferon on tonsils microflora in often ill children].

To estimate the ability of cycloferon to influence a microbiological landscape of tonsils surface in often ill children (OIC), the microflora of tonsils before and after a standard course of this preparation in a group of 68 preschool children classified into OIC category. It is established that the microbe landscape of tonsils surface after a course of cycloferon therapy is characterized by reduction of microflora variety, decrease in bacteria titer (including S. aureus), and reduction ion then number of strains resistant to benzylpenicillin, clindamycin, and vancomycin. Thus, it is possible to recommend cycloferon for rehabilitation of OIC.

[Evaluation of the effectiveness of immunomodulating therapy in children with chronic gastroduodenitis].

The article assesses the effectiveness of administering immunomodulating drug cycloferon in patients aged 10 to 16 years with chronic gastroduodenitis. It is established that the use of cycloferon in children with virus-associated chronic gastroduodenitis leads to a significant increase in T- and B-lymphocyte populations in mucous membranes of the stomach and duodenum, and contributes to the elimination of viruses. This results in reduced severity and activity of inflammation in the mucous membranes and decreases clinical manifestations of the disease.

[Monitoring of side effects and estimation of cycloferon efficacy in treatment of children with frequent and prolonged diseases].

Two hundred fifty patients, including 100 children with frequent and prolonged diseases at the age of 4 to 7 years, 76 children at the age of 7 to 18 years and 74 subjects at the age of 22 to 57 years were observed. The patients were treated with cycloferon in two courses with a 2-week interval according to the standard scheme. The tonsil surface microflora and its susceptibility to antibiotics were determined. Cycloferon lowered the Staphylococcus aureus titre and increased the culture susceptibility to benzylpenicillin, oxacillin, rifampicin, and erythromycin, reducing the variety of the fauces nonpathogenic microflora. The use of cycloferon induced no adverse (pathologic) reactions in 94.8% of the cases. In 4.4% of the children under school age the adverse reactions were transitory and did not require discontinuation of the drug use. Unforeseen reactions were recorded in 0.8% of the children and the use of the drug in them was discontinued. The use of cycloferon in two courses with a 2-week interval according to the standard scheme is recommended for prophylaxis of acute respiratory diseases in the group of children with frequent and prolonged diseases during epidemiologically unfavourable periods and for complex therapy of rhinopharinx infections as an agent increasing efficacy of other antibacterials.

[The biological effect of low-level radiation doses on the morphological composition of the peripheral blood in children]. / Biologicheskii éffekt malykh doz radiatsii na morfologicheskii sostav perifericheskoi krovi u detei.

Examination of 339 children at the age of 2 to 12 years, living in the caesium contaminated region (from 2 to 5 Ci/km2) has revealed that total radioactivity of their urine is, on the average, twice as high as that of children living in "pure" regions. Quantitative and qualitative changes were observed in the erythroid series, neutrophilic leukocytes, eosinophils and B-lymphocytes of the peripheral blood of children subjected to long-term low-level irradiation. It should be noted that the character and direction of these changes were a function of the children's age and the level of total radioactivity of their urine.

[Anthropometric indices of newborns and hormone levels in various periods of ontogenesis]. / Antropometricheskie pokazateli novorozhdennykh i uroven' gormonov v razlichnye periody ontogeneza.

The relationships between anthropometric indices and the hormonal status in ontogenesis were investigated in newborns (137 girls and 151 boys aged 1.5-15); the venous blood levels of cortisol, corticosterone, testosterone, estriol, estradiol, progesterone, triiodothyronine, thyroxin, thyroxin-binding globulin, insulin and somatotropic hormone were determined by radioimmunoassay. At the time of investigation all the infants were practically healthy. Information on body mass and length was obtained from form 112 (Child's Development history). The results have shown that testosterone in boys was genetically determined stronger than in girls. Gene control of body mass and length in the intrauterine period is exercised with the help of the endocrine system. Periodic changing of the dominant genes at subsequent stages of ontogenesis leads to a changed role of certain hormones, directly regulating growth processes.