ABSTRACT
Cytostatic and cytotoxic activity of peripheral blood lymphocytes was studied in 30 cases of lung cancer. Enhanced cytostatic activity of lymphocytes was initially recorded. The level of natural antitumor resistance was maintained by means of neurovegetative inhibition used to prevent surgical stress.
Subject(s)
Cytotoxicity, Immunologic , Lung Neoplasms/immunology , Lymphocytes/immunology , Adult , Autonomic Nerve Block , Cytotoxicity Tests, Immunologic/methods , Humans , Immunity, Innate , Intraoperative Complications/prevention & control , Lung Neoplasms/surgery , Middle Aged , Pentamidine , Stress, Physiological/prevention & controlSubject(s)
Autonomic Nervous System/physiology , Lymphoma, Non-Hodgkin/therapy , Neural Inhibition , Uterine Neoplasms/therapy , Animals , Autonomic Nervous System/drug effects , Female , Humans , Intraoperative Care , Lymphoma, Non-Hodgkin/physiopathology , Male , Neoplasm Transplantation , Neural Inhibition/drug effects , Quaternary Ammonium Compounds , Rats , Rats, Inbred Strains , Uterine Neoplasms/physiopathologyABSTRACT
The relationship between hormone-mediator and immunologic components of homeostasis was studied in 82 surgically-treated cancer patients. The pattern of changes in immunity and non-specific resistance was found to depend on the rate of glucocorticoid hormones synthesis in adrenals. Surgery should be carried out under neurovegetative blockade, which prevents immunodepression both during and shortly after surgery.
Subject(s)
Anesthesia , Neoplasms/physiopathology , Neurotransmitter Agents/blood , Adult , Aged , Anesthesia/adverse effects , Autonomic Nerve Block , B-Lymphocytes/immunology , Female , Humans , Immunity, Innate , Lung Neoplasms/immunology , Lung Neoplasms/physiopathology , Lung Neoplasms/surgery , Male , Middle Aged , Neoplasms/immunology , Neoplasms/surgery , Stomach Neoplasms/immunology , Stomach Neoplasms/physiopathology , Stomach Neoplasms/surgery , T-Lymphocytes/immunologyABSTRACT
The experience with application of gangliolytic drugs in the surgical treatment of 1,380 cancer patients is discussed. It was found that cancer patients' increased sensitivity to the said drugs is due to disorders in neuro-humoral regulation of adaptation and vascular tension as well as occult hypovolemia. These disturbances are intensified with tumor advancement. Recommendations to improve preoperative premedication are given. The dosage of gangliolytic drugs used for anesthesia in cancer patients should be 20-30% lower than that in general surgical cases.
