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Bioorg Med Chem Lett ; 20(8): 2549-51, 2010 Apr 15.
Article in English | MEDLINE | ID: mdl-20346654

ABSTRACT

Non-steroidal compounds that inhibit 17beta-hydroxysteroid dehydrogenase isoform 3 (17beta-HSD3), an enzyme catalyzing the final step in testosterone biosynthesis in Leydig cells, are under development for male contraceptive or treatment of androgen dependent diseases including prostate cancer. A series of curcumin analogues with more stable chemical structures were compared to curcumin as inhibitors of 17beta-HSD3 in rat intact Leydig cells as well as rat and human testis microsomes.


Subject(s)
17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors , Curcumin/analogs & derivatives , Enzyme Inhibitors/pharmacology , Testis/drug effects , Animals , Curcumin/pharmacology , Humans , Male , Rats , Testis/enzymology
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