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Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer.
Yang, Lan-Lan; Liang, Chong-Yang; Lu, Tian-Cheng; Zhi, Chen-Yang; Liu, Bin; Zhou, Jian-Hua; Liu, Xu-Ming; Gao, Hai-Cheng; Huang, Wei.
Mol Med Rep ; 8(6): 1812-6, 2013 Dec.
Article in English | MEDLINE | ID: mdl-24085483

ABSTRACT

The role of tissue transglutaminase (tTG) in cancer development remains an important field of study. The aim of the current study was to understand the involvement of tTG in cancer and the inhibitory effect of cantharidinate on the expression of tTG in human colorectal cancer (CRC) using immunohistochemical and PCR analysis. The results showed that the expression of tTG increased in human CRC and cantharidinate inhibited the expression of tTG. These results suggested that tTG is significant in human CRC and that tTG may be an important target for tumor chemoprevention and treatment. Cantharidinate may be considered as a novel co­therapy for controlling tTG expression in human CRC.


Subject(s)
Cantharidin/therapeutic use , Colorectal Neoplasms/drug therapy , Colorectal Neoplasms/enzymology , GTP-Binding Proteins/metabolism , Transglutaminases/metabolism , Adult , Aged , Aged, 80 and over , Cantharidin/pharmacology , Cell Line, Tumor , Cohort Studies , Colorectal Neoplasms/genetics , Colorectal Neoplasms/pathology , Female , GTP-Binding Proteins/genetics , Gene Expression Regulation, Neoplastic/drug effects , Humans , Immunohistochemistry , Male , Middle Aged , Protein Glutamine gamma Glutamyltransferase 2 , RNA, Messenger/genetics , RNA, Messenger/metabolism , Staining and Labeling , Transglutaminases/genetics , Treatment Outcome , Young Adult
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