1.
Org Biomol Chem
; 21(23): 4874-4880, 2023 Jun 14.
Article
in English
| MEDLINE
| ID: mdl-37249437
ABSTRACT
New P,Nsp3 bidentate ligands containing two chiral carbon centers were developed and applied to palladium-catalyzed asymmetric allylic substitution reactions. Good generalities with various nucleophiles, including carbon, nitrogen and oxygen containing nucleophiles, were achieved with up to 96% ee and 98% yield. This reaction provides an efficient method for the asymmetric formation of C-C, C-N and C-O bonds.