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Org Lett ; 8(20): 4453-6, 2006 Sep 28.
Article in English | MEDLINE | ID: mdl-16986923

ABSTRACT

Przewalskin A (1), a novel C23 terpenoid with a 6/6/7 carbon ring skeleton, was isolated from Salvia przewalskii. Its structure was determined by comprehensive 1D NMR, 2D NMR, and MS spectroscopic analysis and subsequently confirmed by a single-crystal X-ray diffraction study of its PDC oxidation derivative (2). Compounds 1 and 2 showed modest anti-HIV-1 activity with EC50 = 41 and 89 microg/mL, respectively.


Subject(s)
Carbon/chemistry , Cyclohexanones/chemistry , Diterpenes/chemistry , Salvia/chemistry , Terpenes/chemistry , Crystallography, X-Ray , Models, Molecular , Molecular Conformation
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