Porphyrin derivative-based tandem response nanochannels triggered by Zn2+ and NO.

We describe tandem response solid nanochannels tailored with a porphyrin derivative that show Zn2+ and NO gating behaviors with good selectivity, stability, and reversibility. EXAFS and fluorescence experiments showed that zinc coordinated with the porphyrin derivative as the ratio of 1 : 1 with the binding constant for 3.39 × 105 M-1. These studies are beneficial for simulating the physiological functions of ion/gas in organisms and have the potential for designing complicated logic circuits and fabricating novel biosensors.

Highly Emissive Multipurpose Organoplatinum(II) Metallacycles with Contrasting Mechanoresponsive Features.

The development of supramolecular coordination complexes (SCCs) with a bright aggregate state or mechanical-stimuli-responsive luminescence is very significant and challenging. Herein, we report the synthesis of three different supramolecular platinum(II) metallacycles via coordination-driven self-assembly of a diplatinum(II) acceptor and organic donors with a triphenylamine, carbazole, or tetraphenylethylene moiety. The triphenylamine-modified SCC exhibits aggregation-induced emission enhancement (AIEE) but no mechanofluorochromism. The carbazole and tetraphenylethylene-based SCCs exhibit changes in aggregate fluorescence and also exhibit reversible mechanofluorochromism. This work not only reports three rare metallacycles with AIEE, aggregate fluorescence change, or mechanofluorochromic nature but also explores their potential applications in cell imaging and solid-state lighting.

Facile surface functionalization of MXene by pillar[5]arene for enhanced electrochemical performance.

A simple strategy was used to prepare functional two-dimensional materials via the combination of pillar[5]arene (P5) and MXene. The electrochemical results of MXene-P5 exhibit high supramolecular recognition, enrichment capability, and high electrochemical response toward dye molecules, which are probably due to the synergetic effects from high conductivity, high surface area, and host-guest recognition. This study provides a promising electrochemical sensing platform based on different kinds of pillararenes.

[Association between single nucleotide polymorphisms in -88 and -123 loci of MxA gene promoter region and HCV susceptibility and IFN-α efficacy].

AIM: To investigate the association between the single nucleotide polymorphisms(SNP) in -88 and -123 loci of myxovirus resistance 1(MxA) gene promoter region and the susceptibility to heptaitis C virus(HCV) in Han Chinese, and evaluate the relationship between all of the genotypes and the treatment response to IFN-α. METHODS: Genotypes of -88(G/T) and -123(C/A) loci of the MxA promoter were examined by the polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) in 46 patients with chronic hepatitis C(CHC group) and 50 healthy controls(HC group). The indexes for evaluating the curative effect were the biochemical and virological response rates(RVR/EVR/ETVR/SVR). RESULTS: There was no statistical significance in frequency distribution difference of the genotypes and alleles of -88/-123 loci between CHC and CH groups(P>0.05): the T-alleles of MxA-88 locus and the A-alleles of MxA-123 locus may be not associated with the susceptibility to HCV(OR95%CI: 0.60-1.96, 0.35-1.14, respectively). The level of ALT increased and was positively correlated with HCV-RNA load(r=0.931). No significant difference was discovered in terms of the HCV viral load and the ALT levels among different genotypes of -88 or -123 loci(P>0.05). IFN-α treatment response rates were also not significantly different among -88G/T, -123C/A and MxA-88/-123(P>0.05). CONCLUSION: There is no distinct correlation between the SNP of MxA-88G/T and MxA-123C/A loci and HCV susceptibility, but the MxA-88T/-123A gene variants may indirectly increase the risk for HCV infection, and the MxA-88T gene mutation may be related to IFN-α antiviral efficacy and the outcomes of HCV infection.