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Inorg Chem ; 54(14): 6719-26, 2015 Jul 20.
Article in English | MEDLINE | ID: mdl-26146847

ABSTRACT

By using a strategy of introducing hydrophobic groups to the linkers, a hydrostable MOF was constructed based on 5-nitroisophthalate and 2,2'-dimethyl-4,4'-bipyridine coligands, revealing a 3D dia topology structure with a 1D channel parallel to the c axis. TGA, PXRD, and water vapor sorption results show high thermal and water stability for the framework. The framework is very porous and possesses not only high busulfan payloads with an encapsulation efficiency up to 21.5% (17.2 wt %) but also very high CO2 selective capture compared with that of other small gases (i.e., CH4, N2, O2, CO, and H2) at 298 K based on molecular simulations due to the pore surface being populated by methyl and nitryl groups. Furthermore, in vitro MTT assays were conducted on four different cells lines with increasing concentrations of the framework, and the results showed that the framework was nontoxic (cell viability >80%) in spite of the concentrations up to 500 µg/mL.


Subject(s)
Carbon Dioxide/isolation & purification , Drug Carriers/chemistry , Nitrites/chemistry , Organometallic Compounds/chemistry , Phthalic Acids/chemistry , Pyridines/chemistry , Adsorption , Animals , Antineoplastic Agents, Alkylating/administration & dosage , Busulfan/administration & dosage , Cell Survival , Crystallography, X-Ray , Drug Carriers/toxicity , Humans , Mice , Models, Molecular , Nitrites/toxicity , Organometallic Compounds/toxicity , Phthalic Acids/toxicity , Porosity , Pyridines/toxicity
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