ABSTRACT
Long-term treatment of myocardial infarction is challenging despite medical advances. Tissue engineering shows promise for MI repair, but implantation complexity and uncertain outcomes pose obstacles. microRNAs regulate genes involved in apoptosis, angiogenesis, and myocardial contraction, making them valuable for long-term repair. In this study, we find downregulated miR-199a-5p expression in MI. Intramyocardial injection of miR-199a-5p into the infarcted region of male rats revealed its dual protective effects on the heart. Specifically, miR-199a-5p targets AGTR1, diminishing early oxidative damage post-myocardial infarction, and MARK4, which influences long-term myocardial contractility and enhances cardiac function. To deliver miR-199a-5p efficiently and specifically to ischemic myocardial tissue, we use CSTSMLKAC peptide to construct P-MSN/miR199a-5p nanoparticles. Intravenous administration of these nanoparticles reduces myocardial injury and protects cardiac function. Our findings demonstrate the effectiveness of P-MSN/miR199a-5p nanoparticles in repairing MI through enhanced contraction and anti-apoptosis. miR199a-5p holds significant therapeutic potential for long-term repair of myocardial infarction.
Subject(s)
MicroRNAs , Myocardial Infarction , Nanoparticles , MicroRNAs/genetics , MicroRNAs/metabolism , MicroRNAs/administration & dosage , Animals , Myocardial Infarction/genetics , Male , Rats , Nanoparticles/administration & dosage , Nanoparticles/chemistry , Rats, Sprague-Dawley , Apoptosis/drug effects , Myocardium/metabolism , Myocardium/pathology , Disease Models, Animal , Myocardial Contraction/drug effects , Administration, Intravenous , Myocardial Ischemia/genetics , Myocardial Ischemia/therapy , Myocardial Ischemia/metabolismABSTRACT
The electricity-focused input-output model is a popular approach for analysing the socio-economic and environmental impacts of electricity decarbonisation policies; however, it cannot be built directly owing to a lack of data on electricity technology. Here, we provide the Chinese electricity-focused input-output dataset, which characterises the production and distribution of 14 electricity subsectors. Based on the official input-output table for China in 2018, we disaggregate the original electricity sector by referring to macro data from statistics departments and our micro data on the unit-level cost information of China's coal power. This is China's most recent electricity-focused input-output dataset, featuring novel improvements in sub-electricity identification, especially mapping six detailed coal power sources and six alternative power sources. The Chinese electricity-focused input-output dataset can be used as the baseline for extensive satellite account compilation, allowing for a variety of in-depth studies on footprint analysis and policy simulations related to China's electricity transition.
