ABSTRACT
INTRODUCTION: Advances in high-throughput technologies have generated diverse informative molecular markers for cancer outcome prediction. Long non-coding RNA (lncRNA) and DNA methylation as new classes of promising markers are emerging as key molecules in human cancers; however, the prognostic utility of such diverse molecular data remains to be explored. MATERIALS AND METHODS: We proposed a computational pipeline (IDFO) to predict patient survival by identifying prognosis-related biomarkers using multi-type molecular data (mRNA, microRNA, DNA methylation, and lncRNA) from 3198 samples of five cancer types. We assessed the predictive performance of both single molecular data and integrated multi-type molecular data in patient survival stratification, and compared their relative importance in each type of cancer, respectively. Survival analysis using multivariate Cox regression was performed to investigate the impact of the IDFO-identified markers and traditional variables on clinical outcome. RESULTS: Using the IDFO approach, we obtained good predictive performance of the molecular datasets (bootstrap accuracy: 0.71-0.97) in five cancer types. Impressively, lncRNA was identified as the best prognostic predictor in the validated cohorts of four cancer types, followed by DNA methylation, mRNA, and then microRNA. We found the incorporating of multi-type molecular data showed similar predictive power to single-type molecular data, but with the exception of the lncRNA + DNA methylation combinations in two cancers. Survival analysis of proportional hazard models confirmed a high robustness for lncRNA and DNA methylation as prognosis factors independent of traditional clinical variables. CONCLUSION: Our study provides insight into systematically understanding the prognostic performance of diverse molecular data in both single and aggregate patterns, which may have specific reference to subsequent related studies.
Subject(s)
Biomarkers, Tumor/genetics , Breast Neoplasms/diagnosis , Colonic Neoplasms/diagnosis , Lung Neoplasms/diagnosis , Ovarian Neoplasms/diagnosis , Uterine Neoplasms/diagnosis , Biomarkers, Tumor/metabolism , Breast Neoplasms/genetics , Breast Neoplasms/mortality , Breast Neoplasms/pathology , Colonic Neoplasms/genetics , Colonic Neoplasms/mortality , Colonic Neoplasms/pathology , DNA Methylation , Female , Gene Expression Profiling , Humans , Lung Neoplasms/genetics , Lung Neoplasms/mortality , Lung Neoplasms/pathology , MicroRNAs/genetics , MicroRNAs/metabolism , Ovarian Neoplasms/genetics , Ovarian Neoplasms/mortality , Ovarian Neoplasms/pathology , Predictive Value of Tests , Prognosis , Proportional Hazards Models , RNA, Long Noncoding/genetics , RNA, Long Noncoding/metabolism , RNA, Messenger/genetics , RNA, Messenger/metabolism , Survival Analysis , Uterine Neoplasms/genetics , Uterine Neoplasms/mortality , Uterine Neoplasms/pathologyABSTRACT
The quality of technicians is the dominate factor to determine the level of medical engineering section.The key to improving technical skills is to do basic jobs.During the Tenth Five-Year-Plan,we not only did many basic jobs and research works in science but did a lot of revolutions in order to accelerate the development of medical engineering and improve the working quality.Compared with the past,we have made great progress and development in standardized management,technology support,technician education,scientific researches,studies,technology level,the quality of service,etc.
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The paper puts forward the design and application of an imaging analysis system for micro-particles.The structure of the system,design theory and its application are discussed in the paper.
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To combine "the rule of military medical measurement" with the current situation of medical treatment quality control, the foundation, important component and necessary condition of medical treatment quality control was described. Some idiographic advices of intercoordination and communication in medical measurement institution, the direction and training of special technique, and how to develop compulsion coerciveness checking in base course were given. These are valuable for insuring medical treatment facility in hospital.
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Objective To develop ECG Holter system with SD card as storage medium. Methods Data that used MSP430F449 SCM to acquire 3-channel ECG signal to record SD card through serial peripheral interface were reviewed and analyzed on computer. Results Portable ECG Holter System based on SD card is realized. The using of SD card can enhance storage performance. Conclusion Low-cost, and high-performance solution program is observed.
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The quality control methods are the important to improve the exactness of diagnses and the effectivity of treatment.X-ray imaging quality is an important factor in improving the X-ray diagnosis effect.To serve this purpose,medical engineering personnel should do the X-ray quality control regularly to keep every parameter in accordance with national standards and demands.The quality control methods for several important indexes of X-ray generators are also discussed.[Chinese Medical Equipment Journal,2008,29(2):99-101]
