ABSTRACT
Summary Immunoglobulin G4-related disease is a systemic idiopathic inflammatory lesion.It is mainly characterized by infiltration of dense IgG4-positive plasma cells,typical storiform fibrosis,obliterative phlebitis and increased serum levels of IgG4.Patients with IgG4-related disease have frequently multiple organs involvement including structural damages of head and neck.But reports of temporal bone involvement in this kind of disease are rarely seen.This article reviews the recent progress in clinical research of lgG4-related disease in otology.
Subject(s)
Autoimmune Diseases , Immunoglobulin G , Fibrosis , Humans , Neck , Otolaryngology , Plasma CellsABSTRACT
The authors used glycerol (Gly) as a cross linking agent to treat bovine pericardium (BP) and compared it mechanically (tensile test) and biologically (subcutaneous implantation in rats) with glutaraldehyde (Glu) fixed lonescu-Shiley BP (ISBP). Maximum tensile stress (Stmax) was the same in both groups (n = 12 each), while maximum strain (Snmax) was larger in Gly BP. Calcium content (Ca) was lower and water content of tissue (WC) was higher in implants of Gly BP versus ISBP (n = 9 each). Gly BP appeared more hydrated than ISBP in specimens studied by scanning electron microscopy (SEM). In addition, SEM of three Gly BP mitral valves in sheep showed good growth of endothelial (En) cells. These biomechanical advantages of Gly BP over ISBP suggest that Gly may be a useful substitute for Glu in cross linking bovine pericardial valves.
Subject(s)
Bioprosthesis , Cross-Linking Reagents , Glycerol , Heart Valve Prosthesis , Animals , Biomechanical Phenomena , Cattle , Endothelium, Vascular/pathology , Glutaral , Mitral Valve/pathology , Mitral Valve/surgery , Prosthesis Design , SheepABSTRACT
Scanning electron microscopy of bovine pericardium (BP) shows anisotropic collagen fiber orientation (CFO). We studied the effect of CFO on the breaking strength of longitudinal (L) and transverse (T) strips cut from six pieces of fresh (Fr), glutaraldehyde (Glu)-, or formaldehyde (For)-fixed BP loaded at constant rate until rupture. Maximum tensile stress (Stmax) and strain (Snmax) were measured. The Stmax of L strips were larger than T ones in all groups, and Snmax was the same. Similar results were also observed in 10 pieces of Glu fixed normal canine mitral valves (MV). Maximum tensile stress is obtained when the load is parallel to CFO in both canine MV and BP.
