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1.
Epilepsy Behav ; 14(4): 687-90, 2009 Apr.
Article in English | MEDLINE | ID: mdl-19435576

ABSTRACT

An 18-year-old woman presented with epileptic negative myoclonus (ENM) as her major seizure pattern for 4years. Her seizures were characterized by intermittent postural lapse of the right limbs for a period of hours to 2 days. Ictal electroencephalography (EEG)-electromyography showed a silent period that was time-locked to generalized spike-wave discharges. Video/EEG monitoring demonstrated marked improvement of ENM after oral administration of levetiracetam. Cranial magnetic resonance imaging was normal, but 2-deoxy-2-[(18)F]fluoro-d-glucose positron emission tomography during frequent ENM showed hypometabolism in the left frontoparietal cortex. Technetium-99m-ethyl cysteinate dimer single-photon emission computed tomography revealed hyperperfusion over the left parietal cortex and putamen. Here, we document the short-term effects of levetiracetam in this subject with nearly isolated ENM and the neuroimaging results during ENM. Long-term follow-up is in progress to evaluate the clinical evolution and long-term effects of levetiracetam on ENM.


Subject(s)
Anticonvulsants/therapeutic use , Epilepsy , Piracetam/analogs & derivatives , Adolescent , Electroencephalography , Epilepsy/diagnostic imaging , Epilepsy/drug therapy , Epilepsy/physiopathology , Female , Humans , Levetiracetam , Piracetam/therapeutic use , Positron-Emission Tomography , Tomography, Emission-Computed, Single-Photon
3.
Clin Nucl Med ; 30(4): 276-7, 2005 Apr.
Article in English | MEDLINE | ID: mdl-15764891

ABSTRACT

A 74-year-old man underwent low anterior resection for rectal cancer. Technetium-99m methylene diphosphonate (MDP) bone scanning was performed as part of the patient's postoperative follow-up study. Scans revealed an area of increased tracer uptake in the left hemipelvis. Coronal single-photon emission computed tomography and caudal images clearly separated the lesion from the skeletal structures. Transverse magnetic resonance images showed a large diverticulum originating from the left lateral wall of the bladder. The pelvic findings on the bone scan were the result of tracer retained within this diverticulum.


Subject(s)
Bone Neoplasms/diagnostic imaging , Diverticulum/diagnostic imaging , Pelvis/diagnostic imaging , Technetium Tc 99m Medronate , Urinary Bladder Diseases/diagnostic imaging , Aged , Bone Neoplasms/secondary , Diagnosis, Differential , Diverticulum/complications , Humans , Incidental Findings , Male , Radionuclide Imaging , Radiopharmaceuticals , Rectal Neoplasms/diagnostic imaging , Rectal Neoplasms/surgery , Severity of Illness Index , Urinary Bladder Diseases/complications , Whole-Body Counting
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