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1.
Jpn J Radiol ; 36(3): 231-237, 2018 Mar.
Article in English | MEDLINE | ID: mdl-29352406

ABSTRACT

PURPOSE: To evaluate whether traversal through the central part of a pulmonary lesion by a biopsy needle, and other factors, increases the risk of hemoptysis in patients undergoing CT-guided percutaneous transthoracic needle biopsy (PTNB). MATERIALS AND METHODS: From July 2012 to November 2016, 227 patients undergoing 233 procedures were recruited as our study population. Patients were classified according to the occurrence of hemoptysis. Radiological assessments were performed by reviewing multiplanar reconstructed CT images. Other factors complicating PTNB-related hemoptysis were classified into (1) patient-related variables: age, gender, presence of emphysema; (2) lesion-related variables: size, location, distance to pleura, characteristics, presence of and degree of enhancement, histopathology of biopsy results; and (3) procedure-related variables: lesion depth, patient's body position. RESULTS: Twenty-two cases (9.4%) experienced hemoptysis. Univariate analysis revealed that subsolid lesions (p = 0.031) and lesion depth > 1 cm (p = 0.049) were risk factors. Traversal through the central part of the lesion by the biopsy needle was not a risk factor. CONCLUSION: Traversal through the central part of the lesion by the biopsy needle is not a risk factor of PTNB-related hemoptysis, but subsolid lesions and lesion depth > 1 cm increase the risk of hemoptysis.


Subject(s)
Hemoptysis/etiology , Lung Neoplasms/pathology , Radiography, Interventional/methods , Tomography, X-Ray Computed/methods , Aged , Biopsy, Needle/adverse effects , Biopsy, Needle/methods , Female , Humans , Image-Guided Biopsy/adverse effects , Image-Guided Biopsy/instrumentation , Image-Guided Biopsy/methods , Lung/diagnostic imaging , Lung/pathology , Lung Neoplasms/diagnostic imaging , Male , Radiography, Interventional/instrumentation , Risk Factors , Tomography, X-Ray Computed/instrumentation
3.
Synapse ; 59(8): 491-501, 2006 Jun 15.
Article in English | MEDLINE | ID: mdl-16565963

ABSTRACT

The effect of nicotine on evoked glutamate release from isolated nerve terminals (synaptosomes) from rat prefrontal cortex was examined. We found that nicotine significantly potentiated 4-aminopyridine (4AP)-evoked glutamate release, and this potentiatory effect was mimicked by the selective alpha7 nicotinic receptor agonist choline and was blocked by the selective alpha7 nicotinic receptor antagonist methyllycaconitine, indicating its mediation by alpha7 nicotinic receptors. Examination of the effect of nicotine on cytosolic [Ca(2+)] revealed that the potentiation of glutamate release was associated with an increase in voltage-dependent Ca(2+) influx through N- and P/Q-type Ca(2+) channels. The potentiatory effect of nicotine on Ca(2+) influx seems to be attributed to its increasing synaptosomal excitability because nicotine significantly increased depolarization-evoked increase in the intrasynaptosomal free Na(+) concentration and 4AP-evoked depolarization of the synaptosomal plasma membrane potential. Also, Ca(2+) ionophore ionomycin-induced glutamate release was enhanced by nicotine, and this action was blocked by methyllycaconitine. These results suggest that nicotine exerts its potentiatory effect presynaptically, likely through the activation of alpha7 nicotinic receptors, resulting in Na(+) influx and local depolarization, which subsequently enhances the Ca(K+) entry through voltage-dependent N-and P/Q-type Ca(2+) channels as well as the vesicular release machinery to cause an increase in evoked glutamate release from rat prefrontocortical nerve terminals. Moreover, in this release potentiation may involve an activation of Ca(2+)/calmodulin signaling pathway as nicotine-mediated potentiation of 4AP- and ionomycin-evoked glutamate release were significantly attenuated by KN62, a selective inhibitor of Ca(2+)/calmodulin-dependent kinase II.


Subject(s)
Calcium Signaling/physiology , Calmodulin/metabolism , Glutamic Acid/metabolism , Nicotine/pharmacology , Nicotinic Agonists/pharmacology , Synaptosomes/drug effects , 4-Aminopyridine/pharmacology , Animals , Calcium Channels/drug effects , Calcium Channels/metabolism , Male , Membrane Potentials/drug effects , Nicotinic Antagonists/pharmacology , Potassium Channel Blockers/pharmacology , Prefrontal Cortex/drug effects , Prefrontal Cortex/metabolism , Presynaptic Terminals/drug effects , Presynaptic Terminals/metabolism , Rats , Rats, Sprague-Dawley , Receptors, Nicotinic/drug effects , Signal Transduction/physiology , Synaptosomes/metabolism
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