ABSTRACT
Combined drugs with a hydrophilic base, nitacide and hyposol-n, were used in combined therapy of acute purulent inflammations of the maxillofacial area. Time course of clinical parameters and changes in microflora were studied in patients administered different local treatments with different inflammatory reactions. The data indicate a high efficiency of the drugs, which optimized local therapy of suppurative wounds and are recommended for wide practical use.
Subject(s)
Anti-Infective Agents/therapeutic use , Cellulitis/drug therapy , Focal Infection, Dental/drug therapy , Plant Oils/therapeutic use , Stomatognathic Diseases/drug therapy , Thiazoles/therapeutic use , Uracil/analogs & derivatives , Vitamin A , Vitamin E , Vitamin K , Acute Disease , Aerosols , Cellulitis/microbiology , Cellulitis/surgery , Chloramphenicol/therapeutic use , Combined Modality Therapy , Drug Combinations , Face , Focal Infection, Dental/microbiology , Focal Infection, Dental/surgery , Humans , Stomatognathic Diseases/microbiology , Stomatognathic Diseases/surgery , Time Factors , Uracil/therapeutic useABSTRACT
The 25-year experience with the underbandage treatment of soft tissue purulent wounds of various location and genesis with modern ointments with polyethylene glycol as the basis was analyzed. Levocin, levomecole, dioxycole, 5-percent dioxydinic, 1-percent iodopyronic, 0.5-percent quinifuryl and furagel ointments proved to preserve their high activity against aerobic grampositive and gramnegative flora. 10-percent mafenide acetate ointment had a high selective effect on Pseudomonas aeruginosa. The new ointments nitacid and streptonitole containing nitazole and white streptocide were highly active against both aerobic and anaerobic infections. The use of the ointments with the polyethylene glycol as the basis made it possible to decrease 2 times the period of the patient hospitalization in surgical units and to shorten the terms of the systemic antibacterial therapy. The marked therapeutic effect of such ointments due to their high dehydrating capacity and broad antibacterial spectrum enabled to consider them as the drugs of choice in the local treatment of purulent wounds during the 1st phase of the wound process, trophic and decubic ulcers, infected burns, diabetic and atherosclerotic gangrene, furuncles, carbuncles, mastitis, etc. The ointments in the water soluble vehicle can be as well used with success for the prophylactic treatment of infected wounds after the suture. The multitarget effect of the ointments in the water soluble vehicle and their ability to prevent severe purulent complications permitted to consider them as the 1st order drugs in cases of emergency.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Ointments , Polyethylene Glycols , Wound Infection/drug therapy , Clinical Trials as Topic , Humans , Laboratories , Microbial Sensitivity Tests , Treatment OutcomeABSTRACT
Application of 1% of chloramphenicol (gel and cream) for local treatment of Pseudomonas aeruginosa burn infection has been studied in experiment. In vivo, both medical forms show pronounced therapeutic effect, they promote elimination of P. aeruginosa from wounds and decrease inflammation. In noninfected thermal trauma in laboratory animals application of gel and cream of chloramphenicol reduces transition from the phase of inflammation to the phase of reparation by 3-8 days and prevents infection of the burn wound by conditionally pathogenic microflora.
Subject(s)
Anti-Bacterial Agents/administration & dosage , Burns/complications , Chloramphenicol/administration & dosage , Pseudomonas Infections/drug therapy , Animals , Burns/drug therapy , Burns/microbiology , Disease Models, Animal , Drug Evaluation, Preclinical , Gels , Mice , Mice, Inbred CBA , Ointments , Pseudomonas Infections/microbiology , Pseudomonas aeruginosa/isolation & purificationABSTRACT
We have used the combined preparation of foamy aerosol Gyposol-A and nitasol for the prophylaxis of postoperative peritonitis, originated due to gastrojejunal and colo-colonic anastomoses insufficiency. The introduction of preparation via the colonic tube ensures the physical hermetic control of anastomosis and allows to optimize the reparative processes by means of local antimicrobial, antiinflammatory, and stimulant action. Method was used in 76 patients. The frequency of postoperative peritonitis occurrence decreased from 20 to 2.3%.
Subject(s)
Intestine, Large/surgery , Peritonitis/prevention & control , Postoperative Complications/prevention & control , Stomach/surgery , Adult , Aerosols , Aged , Anastomosis, Surgical , Colon/surgery , Female , Humans , Male , Middle Aged , Rectum/surgerySubject(s)
Hemorrhoids/surgery , Intestine, Large/surgery , Surgical Wound Infection/prevention & control , Aerosols , Anti-Bacterial Agents/therapeutic use , Bacteria/drug effects , Bacteria/isolation & purification , Drug Evaluation , Hemorrhoids/complications , Hemorrhoids/microbiology , Humans , Intestine, Large/microbiology , Ointments/therapeutic use , Povidone-Iodine/therapeutic use , Rectum/microbiology , Surgical Wound Infection/microbiologyABSTRACT
In vitro and in vivo antibacterial activity of metronidazole preparations was studied in comparison to that of nitazole in various dosage forms: solution, aerosol, suspension and suppository. The metronidazole preparations inhibited only anaerobic organisms and were efficient in experimental infections caused by them. Unlike the metronidazole preparations, the dosage forms of nitazole inhibited the growth not only of anaerobic organisms but also that of staphylococci and had a therapeutic effect on infections caused by these organisms.
Subject(s)
Anti-Bacterial Agents , Antitrichomonal Agents/pharmacology , Metronidazole/pharmacology , Thiazoles/pharmacology , Aerosols , Animals , Anti-Bacterial Agents/administration & dosage , Antitrichomonal Agents/administration & dosage , Bacteria, Anaerobic/drug effects , Metronidazole/administration & dosage , Ointments , Rabbits , Staphylococcus/drug effects , Suppositories , Tablets , Thiazoles/administration & dosageABSTRACT
Antibacterial properties of the Soviet drug nitazol which is a derivative of imidazole were studied. It was shown that nitazol in a dose of 4-8 micrograms/ml was highly active against gram-negative nonsporulating anaerobes, gram-positive anaerobic cocci and spore-forming Clostridia spp. Unlike metronidazole, it was efficient against both standard and clinical strains of facultative anaerobes such as E. coli, S. aureus and Klebsiella spp. isolated from patients with peritonitis and being poly-resistant to antibiotics. It was found in vitro that the antibacterial effect of nitazol was higher when it was used in combination with some antibiotics. It was demonstrated on experimental models of peritonitis caused by Staphylococcus spp. and E. coli in mice that nitazol used alone or in combination with gentamicin had a favourable effect on the animal survival and lifespan. The combination of nitazol with gentamicin was applied in the combined treatment of appendicular peritonitis in 80 children and its high therapeutic efficacy was stated. Nitazol is useful as an antibacterial drug in the combined treatment of children with purulent peritonitis.
Subject(s)
Disease Models, Animal , Escherichia coli Infections/drug therapy , Gentamicins/therapeutic use , Imidazoles/therapeutic use , Peritonitis/drug therapy , Staphylococcal Infections/drug therapy , Animals , Anti-Infective Agents/therapeutic use , Child , Drug Evaluation, Preclinical , Drug Therapy, Combination , Gentamicins/administration & dosage , Humans , Imidazoles/administration & dosage , MiceABSTRACT
The experimental-clinical investigations have demonstrated the high effectiveness of the native preparation Nitazole against the Gram-negative non-spore-forming anaerobic bacteria, Gram-positive anaerobic cocci, spore-forming Clostridium, certain facultative anaerobes. This permits to recommend it for the use as an antibacterial preparation for the treatment of peritonitis in children.