Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Turk J Gastroenterol ; 30(5): 436-444, 2019 May.
Article in English | MEDLINE | ID: mdl-31060998

ABSTRACT

BACKGROUND/AIMS: Spontaneous viral clearance observed in some patients is one of the variants of the hepatitis C virus (HCV) infection natural history. We aimed to look at the complexity of factors affecting the spontaneous clearance of HCV (SC HCV). MATERIALS AND METHODS: A total of 357 anti-HCV positive patients (309 with chronic hepatitis C and 48 patients with SC HCV) were included into the study. We studied the effects of the interleukin-28B (IL-28B) gene polymorphism, gender, age, the routes of virus transmission, past hepatitis C with jaundice, HCV genotype, and hepatitis B virus (HBV) and HIV co-infection on the outcome of HCV infection. RESULTS: Based on the study results, the SC HCV was found in 48 individuals (13.4%). The most significant positive factors affecting the SC HCV included IL-28B single nucleotide polymorphism (SNP) rs12979860 (CC) and SNP rs8099917 (TT) (OR 4.03, p<0.001) and (OR 3.14, p<0.002), female gender (OR 2.72, p<0.001), young age (OR 2.30, p<0.008), and past history of jaundice (OR 5.12, p<0.001). The markers of a past HBV infection were found significantly more often in SC. CONCLUSION: Positive predictors of the SC HCV include favorable IL-28B genotype, female gender, young age, a history of jaundice, markers of a past HBV infection, the absence of HIV infection, but not the viral genotype.


Subject(s)
HIV Infections/genetics , Hepacivirus/genetics , Hepatitis B/genetics , Hepatitis C, Chronic/genetics , Interferons/genetics , Adult , Age Factors , Coinfection/genetics , Coinfection/virology , Female , Genotype , HIV , HIV Infections/virology , Hepatitis B/virology , Hepatitis B virus , Hepatitis C, Chronic/virology , Humans , Jaundice/genetics , Jaundice/virology , Male , Middle Aged , Polymorphism, Single Nucleotide , Remission, Spontaneous , Sex Factors , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL
...