[Effect of the enterosorbent Aqualen on intestinal carcinogenesis induced by 1,2-dimethylhydrazine in rats]. / Tormoziashchee vliianie voloknistogo énterosorbenta Aqualen na kantserogenez kishechnika, inditsiruemyi 1,2-dimetylgidrazinom u krys.

Subcutaneous injections of 21 mg/kg 1,2-dimethylhydrazine were given weekly to 134 female LI0 rats. In the first series, 73 rats received 15 injections while 63 animals--5 injections (series 11). Some rats were also fed Aqualen (0.1 or 1.0 g/kg b.w.) during the whole experiment (6 months). In run 1, all animals developed malignant tumors of the colon. However, multiple tumors in Aqualen-fed rats were significantly less frequent than in those receiving carcinogenic agent alone. Also, Aqualen appeared to inhibit the development of carcinoma in the small intestine. In run 11, Aqualen treatment was followed by decreased incidence and multiplicity of tumors both in the entire large intestine and ascending and descending colon. Rectal tumor incidence was lower, too. In both runs, tumor size in enterosorbent-fed animals was smaller than in controls. All intestinal tumors were adenocarcinomas. No pathology was observed in Aqualen-fed rats untreated with the carcinogenic agent.

[Effect of the fibrinous sorbent Akvalen on survival and spontaneous tumorigenesis in mice]. / Vliianie voloknistogo sorbenta Akvalen na prodolzhitel'nost' zhizni i vozniknovenie spontannykh opukholei u myshei.

SHP female mice were fed 100 mg/kg carbonic fibrilous sorbent Akvalen 5 times a week, from the age of 3 months until death. The treatment failed to have a significant influence on body weight dynamics or mean lifespan. However, sorbent-treated animals survived 4 months longer until 90% of them died. Although there were no significant differences in the frequency of either all or only malignant tumors between study group and controls, the former showed fewer multiple tumors (1.4 times) as well as a tendency of decreased incidence of neoplasms of the hemopoietic system and uterine polyps. Tumor-bearing sorbent-treated mice survived 4 months longer, while those with malignant tumors only survived 5 months longer (p < 0.05). The investigation failed to detect any carcinogenicity of Akvalen. It is suggested that the sorbent possesses certain geroprotective and anti-tumor properties.