ABSTRACT
Platelets contain growth factors released during their degranulation following activation. These growth factors promote tissue remodeling, wound healing and angiogenesis. Currently, the clinical effect of Platelet-Rich Plasma (PRP) is still discussed, or even controversial. Our researches have assessed the effectiveness of PRP on the healing of animal tendons and human beings suffering from chronic jumper's knee.
Subject(s)
Platelet-Rich Plasma , Tendinopathy/therapy , Animals , Chronic Disease , Male , RatsABSTRACT
For decades, incompressibility has been a major assumption in the mechanical study of brain tissue. This assumption is based on the hydrated nature of the biological tissues and the incompressibility of fluids. In this paper, an experimental validation of this assumption using digital image correlation is presented. Unconfined compression tests, relaxation tests and cyclic tests were performed on cylindrical samples of swine brains at loading rates suitable for neurosurgical applications. Digital image correlation was used to evaluate the evolution of the volume ratio throughout the tests. The preparation of the samples is described and it is demonstrated that it causes no statistically significant change of their mechanical properties. The results indicate that the brain tissue incompressibility assumption is verified.
