[Surgical treatment of a patient with mandibular micrognathia accompanied by obstructive sleep apnea syndrome using extended genioplasty]. / Khirurgicheskoe lechenie patsienta s mikrognatiei nizhnei chelyusti i sindromom obstruktivnogo apnoe vo sne metodom rasshirennoi genioplastiki.

A method for diagnosing, planning and surgical treatment of patients with micrognathia of the mandible with physiological occlusion is proposed, which makes it possible to objectively assess the severity of the anomaly and concomitant functional disorders of external respiration in the nasopharynx and oropharynx, as well as to identify the pathophysiological mechanisms of obstructive sleep apnea syndrome (OSAS) and develop an optimal surgical treatment plan with high functional and aesthetic results.

[Applications of the lipofilling method in the rehabilitation of patients with defects and scar deformities of the terminal part of the nose]. / Primeneniya metoda lipofilinga v reabilitatsii patsientov s defektami i rubtsovymi deformatsiyami kontsevogo otdela nosa.

A clinical case of the treatment of a 30-year-old patient with a diagnosis of a defect and cicatricial deformity of the terminal part of the nose, deviated septum with a defect in the cartilaginous part, valvular insufficiency and hypertrophy of the inferior turbinates is presented. Reconstructive surgery of the terminal part of the nose using cartilage autografts required special preparation of scar soft tissues of the nose. For this purpose, the method of lipofilling was used as an additional stage in the complex rehabilitation of patients with postoperative defects and deformities of the terminal section.

[Methodology for the use of kinesiological decongestant dressing in double-jaw orthognathic operations]. / Metodika primeneniya kineziologicheskoi protivootechnoi povyazki pri dvukhchelyustnykh ortognaticheskikh operatsiyakh.

OBJECTIVE: Development and implementation in practice of a technique for applying a postoperative decongestant kinesiological bandage. MATERIALS AND METHODS: A comparative analysis of the effectiveness of the developed methodology was carried out. Three groups of patients were formed, consisting of 20 people. The first group of patients received a kinesiological bandage after surgery. The second group used a pressure bandage, while the third group used a chilotherapeutic cooling mask. RESULTS: The average value of the volume of postoperative edema (in cm) on the 5th day after surgery was 10.9 in the first group; 11.4 in the second group; 11.1 in the third group. On the 10th day the corresponding values were 10.7, 11.2 and 11 cm in the third group. CONCLUSIONS: The revealed indicators of average values in the three studied groups proved that the proposed method of applying the decongestant kinesiology dressing has the most pronounced effectiveness in the postoperative period.

[«Surgery First¼ or two-stage protocol for the comprehensive rehabilitation of patients with combined deformities of the jaws]. / «Surgery First¼ ili dvukhetapnyi protokol kompleksnoi reabilitatsii patsientov s sochetannymi deformatsiyami chelyustei.

The review article examines the methodology for the complex treatment of patients with occlusion anomalies without prior orthodontic treatment, the problems of treating patients with combined jaw deformities, the history of the development and appearance of orthognathic surgery, the prerequisites for the emergence of a two-stage treatment method. Differences between two-step and classic treatment protocols. The authors described the problems associated with the use of the two-stage treatment method, the advantages of the two-stage treatment method in comparison with the classic three-stage approach, examined the goals, objectives and differences of orthodontic treatment, identified the problems associated with the implementation of this treatment method.

[Total excision of parotid salivary gland saving ramus of n. facialis in the case of pharyngeal processus tumor].

The article describes the method of surgical treatment of patients with huge tumors of pharyngeal processus of parotid gland saving ramus of n. facialis. The method allows avoiding mandibular osteotomy without relapse risk it supposes the total excision of the gland.

[Diagnostics and treatment of patients with mandible salient angles].

Problem of diagnostics and treatment of patients with disproportion of lower face zone was discussed which was expressed in the form of mandible salient angles and produced aesthetic problem to many people especially to womanhood. Complex of diagnostic methods was offered that gave the possibility to differentiate types of pathology into groups for easing method of treatment chose. Methods of treatment were listed allowing to receive high aesthetic and functional results.

Resistance pathways of human immunodeficiency virus type 1 against the combination of zidovudine and lamivudine.

A better understanding of human immunodeficiency virus type 1 drug-resistance evolution under the selective pressure of combination treatment is important for the design of long-term effective treatment strategies. We applied Bayesian network learning to sequences from patients treated with the reverse transcriptase inhibitor combination of zidovudine (AZT) and lamivudine (3TC) to identify the role of many treatment-selected mutations in the development of resistance. Based on the Bayesian network structure, an in vivo fitness landscape was built, reflecting the necessary selective pressure under treatment, to evolve naive sequences to sequences obtained from patients treated with the combination. This landscape, combined with an evolutionary model, was used to predict resistance evolution in longitudinal sequence pairs. In our analysis, mutations 41L, 70R, 184V and 215F/Y were identified as major resistance mutations to the combination of AZT and 3TC, as they were associated directly with treatment experience. The network also suggested a possible role in resistance development for a number of novel mutations. Estimated fitness, using the landscape, correlated significantly with in vitro resistance phenotype in genotype-phenotype pairs (R(2)=0.70). Variation in predicted evolution under selective pressure correlated significantly with observed in vivo evolution during AZT plus 3CT treatment. In conclusion, we confirmed current knowledge on resistance development to the combination of AZT and 3CT, but additional novel mutations were identified. Moreover, a model to predict resistance evolution during AZT and 3CT treatment has been built and validated.

[Comprehensive approach to treatment of patients with teeth-jaws anomalies accompanied by nose functional disturbances and esthetic deformations].

Problem of medical rehabilitation of patients with teeth-jaws anomalies accompanied by nose functional disturbances and esthetic deformations was viewed. Method of comprehensive reconstructive intervention on facial cranium was presented allowing to restore correct jaws relationship to cranium base. Correction of nasal and endonasal structures was performed, functions of nasal breathing and esthetic face parameters as a whole were restored. Comprehensive approach to planning and carrying out surgical treatment let to receive high esthetic and functional results.