ABSTRACT
Salicylazosulfapyridine (SASP) is a drug used in the treatment of ulcerative colitis (UC) owing to the therapeutic action of the 5-aminosalicylic acid produced by the splitting of the molecule in the cecum, which also yields the absorbable compound Sulphapyridine (SP). The aim of our work was to assess the levels of the drug in blood (SASP and SP), to correlate them with undesirable effects in any, to verify their fluctuations in the dosing interval and to investigate the extent of the excretion of the drug in the children who were studied. 10 children (6 to 16 years) with UC, who were treated with SASP (dOsage schedule 0.5-2.0 g/day in a 12 hours interval), were studied. Blood levels of SASP and SP were assessed at 6 and 12 hours after doses, and total fecal excretion of SASP was determines in 24 hs specimens. All the determinations were performed according to Hansson and Sandberg. SP plasma levels were 17.7 +/- 9.0 ug/ml (range 6.8-36.3 ug/ml) at 6 hours after doses. and 14.1 +/- 7.2 ug/ml (range 5.7-25.0 ug/ml) at 12 hours after doses. SASP plasma levels were 15.5 +/- 15.4 ug/ml (range 2.1-53.4 ug/ml) at 6 hours after doses, and 14.0 +/- 20.4 ug/ml (range 3.9-70.7 ug/ml) at 12 hours after doses. The 24 hours fecal excretion was 17.4 to 236 mg. These values were correlated with the given doses (r = 0.88) calculated as SASP g/m2 body surface 24 hs. There was no statistical correlation between doses and SP or SASP levels in this group, and the respective levels of SASP and SP at 6 and 12 hours after doses showed no significative differences.(ABSTRACT TRUNCATED AT 250 WORDS)
Subject(s)
Colitis, Ulcerative/drug therapy , Sulfanilamides/blood , Sulfapyridine/blood , Sulfasalazine/blood , Adolescent , Child , Colitis, Ulcerative/blood , Humans , Sulfapyridine/administration & dosage , Sulfapyridine/pharmacokinetics , Sulfasalazine/administration & dosage , Sulfasalazine/pharmacokineticsABSTRACT
Salicylazosulfapyridine (SASP) is a drug used in the treatment of ulcerative colitis (UC) owing to the therapeutic action of the 5-aminosalicylic acid produced by the splitting of the molecule in the cecum, which also yields the absorbable compound Sulphapyridine (SP). The aim of our work was to assess the levels of the drug in blood (SASP and SP), to correlate them with undesirable effects in any, to verify their fluctuations in the dosing interval and to investigate the extent of the excretion of the drug in the children who were studied. 10 children (6 to 16 years) with UC, who were treated with SASP (dOsage schedule 0.5-2.0 g/day in a 12 hours interval), were studied. Blood levels of SASP and SP were assessed at 6 and 12 hours after doses, and total fecal excretion of SASP was determines in 24 hs specimens. All the determinations were performed according to Hansson and Sandberg. SP plasma levels were 17.7 +/- 9.0 ug/ml (range 6.8-36.3 ug/ml) at 6 hours after doses. and 14.1 +/- 7.2 ug/ml (range 5.7-25.0 ug/ml) at 12 hours after doses. SASP plasma levels were 15.5 +/- 15.4 ug/ml (range 2.1-53.4 ug/ml) at 6 hours after doses, and 14.0 +/- 20.4 ug/ml (range 3.9-70.7 ug/ml) at 12 hours after doses. The 24 hours fecal excretion was 17.4 to 236 mg. These values were correlated with the given doses (r = 0.88) calculated as SASP g/m2 body surface 24 hs. There was no statistical correlation between doses and SP or SASP levels in this group, and the respective levels of SASP and SP at 6 and 12 hours after doses showed no significative differences.(ABSTRACT TRUNCATED AT 250 WORDS)
ABSTRACT
Se estudiaron 24 niños de 10 días a 14 años de edad (x: 5.5.años), 16 varones y 8 mujeres, que fueron internados en nuestro Servicio por afectaciones extradigestivas para control de su cuadro clínico. Se determinó creatinina y amilasa en suero y orina de 24 horas, y lipasa sérica. Los valores del clearance de amilasa-creatinina oscilaron entre 1.3 y 5.8% (x:3 3.1 ñ 1.3). Los resultados de la amilasemia variaron de 36 a 460 U/I (x 123). Cinco pacientes presentaron hiperamilasemia: dos de ellos con parotiditis urliana, 2 se encontraban en control clínico de un post-quirúrgico, y el quinto, una meningitis bacteriana. Todos ellos, presentaron clearance de amilasa-creatinina de hasta 2.5%. La determinación de lipasa fue de 6 a 197 U/I (x 79), siendo todos los valors normales. Conclusiones: La hiperamilasemia no es patognomónica a nivel pediátrico de afectación pancreática; la lipasemia y el clearance de amilasa-creatinina parecen dos parámetros útiles para descartar compromiso pancreático en pacientes con hiperamilasemia
Subject(s)
Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Humans , Male , Female , Amylases/metabolism , Creatinine/metabolism , Lipase/blood , Pancreatic Diseases/diagnosis , Pancreas/pathology , Pancreas/physiopathology , UltrasonographyABSTRACT
Se estudiaron 24 niños de 10 días a 14 años de edad (x: 5.5.años), 16 varones y 8 mujeres, que fueron internados en nuestro Servicio por afectaciones extradigestivas para control de su cuadro clínico. Se determinó creatinina y amilasa en suero y orina de 24 horas, y lipasa sérica. Los valores del clearance de amilasa-creatinina oscilaron entre 1.3 y 5.8% (x:3 3.1 ñ 1.3). Los resultados de la amilasemia variaron de 36 a 460 U/I (x 123). Cinco pacientes presentaron hiperamilasemia: dos de ellos con parotiditis urliana, 2 se encontraban en control clínico de un post-quirúrgico, y el quinto, una meningitis bacteriana. Todos ellos, presentaron clearance de amilasa-creatinina de hasta 2.5%. La determinación de lipasa fue de 6 a 197 U/I (x 79), siendo todos los valors normales. Conclusiones: La hiperamilasemia no es patognomónica a nivel pediátrico de afectación pancreática; la lipasemia y el clearance de amilasa-creatinina parecen dos parámetros útiles para descartar compromiso pancreático en pacientes con hiperamilasemia (AU)
Subject(s)
Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Humans , Male , Female , Amylases/metabolism , Creatinine/metabolism , Lipase/blood , Pancreatic Diseases/diagnosis , Ultrasonography , Pancreas/physiopathology , Pancreas/pathologyABSTRACT
UNLABELLED: 24 children whose ages ranged from 10 days to 14 years (x 5.5. ys.), 16 males and 8 females, hospitalized in our Service on account of extra-digestive were studied. Creatinine and amylase determination were performed on serum and 24 hs. urine specimens; lipase activity was measured only in serum. Amylase-creatinine clearance ratio varied between 1.3 and 5.8% (x 3.1 +/- 1.3). Serum amylase ranged from 36 to 460 U/l (x 123 U/l). Five patients had hyperamylasemia. 2 were urlian parotiditis, 2 were under clinical surveillance after surgery and the last one was a septic meningitis. All of them showed amylase-creatinine ratio values up to 2.5%. Serum lipase ranged from 6 to 197 U/l (x 79 U/l), falling into the normal interval. No abnormal clearance was found. CONCLUSIONS: hyperamylasemia is not specific for pancreatic disturbances in children; the serum lipase and the amylase-creatinine clearance ratio seem to be useful tools to rule out pancreatic involvement in hyperamylasemic patients.
Subject(s)
Amylases/metabolism , Creatinine/metabolism , Lipase/blood , Pancreatic Diseases/diagnosis , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Pancreatic Diseases/metabolism , UltrasonographyABSTRACT
24 children whose ages ranged from 10 days to 14 years (x 5.5. ys.), 16 males and 8 females, hospitalized in our Service on account of extra-digestive were studied. Creatinine and amylase determination were performed on serum and 24 hs. urine specimens; lipase activity was measured only in serum. Amylase-creatinine clearance ratio varied between 1.3 and 5.8
(x 3.1 +/- 1.3). Serum amylase ranged from 36 to 460 U/l (x 123 U/l). Five patients had hyperamylasemia. 2 were urlian parotiditis, 2 were under clinical surveillance after surgery and the last one was a septic meningitis. All of them showed amylase-creatinine ratio values up to 2.5
. Serum lipase ranged from 6 to 197 U/l (x 79 U/l), falling into the normal interval. No abnormal clearance was found. Conclusions: hyperamylasemia is not specific for pancreatic disturbances in children; the serum lipase and the amylase-creatinine clearance ratio seem to be useful tools to rule out pancreatic involvement in hyperamylasemic patients.
ABSTRACT
El diagnostico etiologico de la constipacion implica examen clinico y metodologias complejas y agresivas (tacto rectal, manometria, endoscopia y biopsia quirurgica). El aumento de la concentracion de acetilcolinesterasa (AChE)en los plexos mientericos y submucosa en la enfermedad de Hirschprung ha sido utilizado en el diagnostico diferencial de la constipacion.Se estudiaron 27 pacientes constipados con metodos convencionales y determinacion de AChE en mucosa rectal con el metodo de Ellman, divididos en dos grupos. Grupo 1: 20 pacientes de 5 meses a 15 anos de edad.Grupo 2: 6 pacientes con diagnostico de enfermedad de Hirschprung, de 4 meses a 7 anos de edad. El restante paciente de 18 meses de edad con constipacion cronica y retraso de la eliminacion de meconio fue un seudo-Hirschprung. El valor medio de las determinaciones en el grupo I fue de 8,5 con un desvio estandar de 1,9 x 10 mol/min/g. En el grupo II fue de 25.0 con um desvio estandar de 5.2 x 10 mol/min/g. Los resultados evidencian diferencias significativas entre ambos grupos (p <0,001). Pensamos que este metodo puede ser utilizado en el diagnostico etiologico de rutinas de la constipacion, como senala la bibliografia
Subject(s)
Infant , Child, Preschool , Child , Humans , Male , Female , Acetylcholinesterase , Constipation , Ganglia, Parasympathetic , MegacolonSubject(s)
Infant, Newborn , Infant , Humans , Male , Female , Hepatitis , Jaundice, Neonatal , Cholestasis, ExtrahepaticABSTRACT
El diagnostico etiologico de la constipacion implica examen clinico y metodologias complejas y agresivas (tacto rectal, manometria, endoscopia y biopsia quirurgica). El aumento de la concentracion de acetilcolinesterasa (AChE)en los plexos mientericos y submucosa en la enfermedad de Hirschprung ha sido utilizado en el diagnostico diferencial de la constipacion.Se estudiaron 27 pacientes constipados con metodos convencionales y determinacion de AChE en mucosa rectal con el metodo de Ellman, divididos en dos grupos. Grupo 1: 20 pacientes de 5 meses a 15 anos de edad.Grupo 2: 6 pacientes con diagnostico de enfermedad de Hirschprung, de 4 meses a 7 anos de edad. El restante paciente de 18 meses de edad con constipacion cronica y retraso de la eliminacion de meconio fue un seudo-Hirschprung. El valor medio de las determinaciones en el grupo I fue de 8,5 con un desvio estandar de 1,9 x 10 mol/min/g. En el grupo II fue de 25.0 con um desvio estandar de 5.2 x 10 mol/min/g. Los resultados evidencian diferencias significativas entre ambos grupos (p <0,001). Pensamos que este metodo puede ser utilizado en el diagnostico etiologico de rutinas de la constipacion, como senala la bibliografia
Subject(s)
Infant , Child, Preschool , Child , Humans , Male , Female , Acetylcholinesterase , Constipation , Ganglia, Parasympathetic , MegacolonSubject(s)
Infant, Newborn , Infant , Humans , Male , Female , Cholestasis, Extrahepatic , Hepatitis , Jaundice, NeonatalSubject(s)
Hepatitis/pathology , Acute Disease , Adolescent , Biopsy, Needle , Child , Child, Preschool , Female , Follow-Up Studies , Hepatitis B/immunology , Hepatitis B/pathology , Hepatitis B Surface Antigens/analysis , Humans , Infant , Male , Necrosis , PrognosisABSTRACT
527 patients whose ages ranged from 3 months to 5 years, with acute diarrhea were studied. 517 showed satisfactory response to treatment. Diarrhea persisted in 10 patients (2 %) and bile acids were determined in intestinal juice before and after cholestyramine administration. 7 patients showed bile acids deconjugation, 6 of which cured clinically. 3 patients showed no deconjugation, and 1 of them improved after cholestyramine therapy. Side effects of drug were not observed.
Subject(s)
Bile Acids and Salts/analysis , Cholestyramine Resin/therapeutic use , Diarrhea, Infantile/drug therapy , Acute Disease , Bile Acids and Salts/pharmacology , Child, Preschool , Cholestyramine Resin/pharmacology , Female , Gastric Juice/analysis , Humans , Infant , MaleABSTRACT
527 patients whose ages ranged from 3 months to 5 years, with acute diarrhea were studied. 517 showed satisfactory response to treatment. Diarrhea persisted in 10 patients (2
) and bile acids were determined in intestinal juice before and after cholestyramine administration. 7 patients showed bile acids deconjugation, 6 of which cured clinically. 3 patients showed no deconjugation, and 1 of them improved after cholestyramine therapy. Side effects of drug were not observed.
ABSTRACT
527 patients whose ages ranged from 3 months to 5 years, with acute diarrhea were studied. 517 showed satisfactory response to treatment. Diarrhea persisted in 10 patients (2
) and bile acids were determined in intestinal juice before and after cholestyramine administration. 7 patients showed bile acids deconjugation, 6 of which cured clinically. 3 patients showed no deconjugation, and 1 of them improved after cholestyramine therapy. Side effects of drug were not observed.
