1.
J Chemother
; 19(5): 514-8, 2007 Oct.
Article
in English
| MEDLINE
| ID: mdl-18073150
ABSTRACT
The in vitro activity of the peptide IB-367, alone or combined with either fluconazole (FLU) or amphotericin B (AMB), was investigated against 25 Candida isolates belonging to five species. IB-367 minimum inhibitory concentrations (MICs) ranged from 2.0 to 32 microg/ml and it was active against both FLU-susceptible and - resistant isolates. A rapid fungicidal activity was observed. Synergism was documented in 41.6% and 44% of IB-367/FLU and IB-367/AMB interactions, respectively. Antagonism was never observed. The broad antifungal activity and the positive interactions with AMB and FLU suggest that IB-367 represents a promising candidate against infections due to Candida spp.
Subject(s)
Antifungal Agents/pharmacology , Candida/drug effects , Peptides/pharmacology , Amphotericin B/administration & dosage , Antimicrobial Cationic Peptides , Candidiasis/drug therapy , Drug Resistance, Fungal , Drug Synergism , Drug Therapy, Combination , Fluconazole/administration & dosage , Humans , In Vitro Techniques , Microbial Sensitivity Tests
2.
Minerva Pediatr
; 35(9): 413-21, 1983 May 15.
Article
in Italian
| MEDLINE
| ID: mdl-6877201
3.
Minerva Pediatr
; 32(2): 133-8, 1980 Jan 31.
Article
in Italian
| MEDLINE
| ID: mdl-7382933