1.
Bioorg Med Chem Lett
; 11(17): 2235-9, 2001 Sep 03.
Article
in English
| MEDLINE
| ID: mdl-11527705
ABSTRACT
The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) are extremely potent against both wild-type and a panel of clinically significant single- and double-mutant strains of HIV-1.
Subject(s)
Anti-HIV Agents/chemistry , Anti-HIV Agents/pharmacology , Nitriles/chemistry , Nitriles/pharmacology , Pyrimidines/chemistry , Pyrimidines/pharmacology , Drug Evaluation, Preclinical , HIV Reverse Transcriptase/antagonists & inhibitors , HIV Reverse Transcriptase/drug effects , HIV Reverse Transcriptase/genetics , HIV-1/drug effects , HIV-1/genetics , Inhibitory Concentration 50 , Mutation , Reverse Transcriptase Inhibitors/chemistry , Reverse Transcriptase Inhibitors/pharmacology , Structure-Activity Relationship
2.
Pediatr Nurs
; 12(1): 41-8, 69, 1986.
Article
in English
| MEDLINE
| ID: mdl-3633072