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3.
Article in Russian | MEDLINE | ID: mdl-2461625

ABSTRACT

In 39 children with coma caused by infectious toxicosis, purulent meningoencephalitis and closed head trauma the brain-specific antigens (L1M and L2M globulins) contents were studied in the blood serum and cerebrospinal fluid (CSF). On days 3 to 5 after the head trauma L1M and L2M were found irregularly. In meningoencephalitis L1M and L2M were detected with a lesser delay. In infectious toxicosis L1M and L2M appeared in blood serum and CSF regularly and early. The data suggest that appearance of brain-specific antigens in blood and CSF in coma reflect a rise in the blood-brain barrier permeability to CSF-blood transport.


Subject(s)
Blood-Brain Barrier , Brain/immunology , Cell Membrane Permeability , Coma/immunology , Epitopes/analysis , Alpha-Globulins/analysis , Brain Injuries/complications , Brain Injuries/immunology , Brain Injuries/physiopathology , Child , Child, Preschool , Coma/etiology , Coma/physiopathology , Humans , Infant , Meningoencephalitis/complications , Meningoencephalitis/immunology , Meningoencephalitis/physiopathology , Virus Diseases/complications , Virus Diseases/immunology , Virus Diseases/physiopathology
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