[Degradation and residue dynamics of the anthelminthic 131J-rafoxanide in cattle blood, milk, meat and fat after various dosages]. / Abbau und Rückstandsdynamik des Anthelminthikums 131J-Rafoxanid in Blut, Milch, Fleisch und Fett bei unterschiedlicher Dosierung am Rind.

Rafoxanide, labelled by 131J, was applied orally in oily solution to cattle, 2,4 and 12 mg/kg bodymass, resp. The halflifes of degradation in blood is depending on the dosage and is 7 days related to the therapeutical dosage of 5 mg/kg bodymass against Fasciola hepatica. Residues and halflifer in blood, milk, meat and fat are given, related to 131J in the chloroform extract. Rafoxanide does not show persistence following oral application to cattle.

[Degradation and elimination of the anthelminitic 131I-rafoxanid in cattle and sheep]. / Untersuchungen zum Abbau und zur Ausscheidung des Anthelminthikums 131J-Rafoxanid an Rind und Schaf

Rafoxanide, labelled by 131J, was applied orally in oily solution to cattle and sheep, 12 and 17 mg/kg bodymass, resp. The half time of 131J in blood in 12,5 and 10,5 d for sheep and cattle, resp., the compound is adsorbed to proteins in blood. In the milk a maximal level of 3-3,5 ppm (calculated as total 131J) after 4-6 d was measured. More detailed results regarding the metabolism of rafoxanide are hitherto not possible.