Subject(s)
Dermoid Cyst/diagnostic imaging , Neoplasms, Multiple Primary/diagnostic imaging , Ovarian Neoplasms/diagnostic imaging , Struma Ovarii/diagnostic imaging , Thyroid Neoplasms/diagnostic imaging , Adenocarcinoma/diagnostic imaging , Adult , Female , Humans , Iodine Radioisotopes , Radionuclide ImagingABSTRACT
Accumulation of Tc-99m MDP in soft tissue malignancies occurs frequently. When tumor overlaps adjacent bone structures, the bone margins can be indiscernible on a regular bone scan. Additional views should be taken to differentiate bone from tumor, however, separation is sometimes difficult and not always successful. This report presents a patient in whom accumulation of Tc-99m MDP in a liposarcoma of the thigh disappeared on a 24 hour scan and bone margins were seen clearly. A possible mechanism for this phenomenon and its utility are discussed.
Subject(s)
Femoral Neoplasms/diagnostic imaging , Liposarcoma/diagnostic imaging , Soft Tissue Neoplasms/diagnostic imaging , Adult , Female , Humans , Radionuclide Imaging , Technetium Tc 99m Medronate , Thigh , Time FactorsSubject(s)
Education/standards , Achievement , Child, Exceptional/education , Educational Measurement , HumansABSTRACT
We studied the distribution of 111In-labeled peritoneal mononuclear cells (PMC) in Sprague-Dawley rats with carcinosarcoma (CS) tumor. We obtained PMC from normal rats and rats pretreated with BCG or irradiated CS cells as antigenic stimulant. PMC were labeled in-vitro with 111In-oxine and transferred by tail-vein injection to rats bearing CS tumor. Twenty-four, 48 and 72 h after PMC transfer, we measured the accumulation of these cells in the CS tumor as a percentage of dose radioactivity per gram of tumor using an external gamma-ray camera. PMC from normal and BCG treated donor rats accumulated 0.4% and 0.46% dose per gram of CS tumor respectively. PMC from donor rats given killed CS cells accumulated significantly greater concentrations of 111In (0.79% dose per gram of CS tumor, P less than 0.025). Thus killed CS cells were able to sensitize the PMC of normal rats. 111In-oxine-labeling is an elegant procedure to study the distribution of mononuclear cells in tumors.
Subject(s)
Hydroxyquinolines/metabolism , Indium/metabolism , Monocytes/metabolism , Organometallic Compounds , Oxyquinoline/metabolism , Animals , Carcinosarcoma/metabolism , Female , Kinetics , Macrophages/metabolism , Oxyquinoline/analogs & derivatives , Radioisotopes , Rats , Rats, Inbred Strains , Tissue DistributionABSTRACT
Optometrists cannot effectively serve children with learning problems in isolation. Through integrated input from multidisciplinary sources, the optometrist can develop an appropriate vision care program for these children.
Subject(s)
Child Health Services , Optometry , Patient Education as Topic , Ambulatory Care Facilities , Child , Humans , Vision TestsSubject(s)
Education, Special , Learning Disabilities/diagnosis , Terminology as Topic , Child , Humans , United StatesABSTRACT
Scintigraphy with indium-111-labeled leukocytes (In-111-WBC) was assessed in 128 patients with suspected abdominal-pelvic abscesses. Studies were positive in 37 of 41 patients with proved abscesses, in two of two with infected aortic grafts, and in 12 of 15 with other infections; studies were negative in 63 of 70 cases without infection. The sensitivity of leukocyte scintigraphy in this series was 88%, specificity 90%, and accuracy 89%. Sixteen percent of all patients studied with In-111-WBC scintigraphy had unexpected sites of infection outside the abdomen. Of the 58 patients with proved infection, 20 (34%) had alterations in diagnostic evaluations and therapeutic regimens due to such findings.
Subject(s)
Abscess/diagnostic imaging , Indium , Infections/diagnostic imaging , Leukocytes , Radioisotopes , Abdomen/diagnostic imaging , Humans , Middle Aged , Pelvis/diagnostic imaging , Radionuclide Imaging , Retrospective StudiesABSTRACT
Radionuclide scintigraphy is a safe and accurate means of detecting postoperative urologic complications in renal transplant recipients. Early identification of urinary leakage coupled with aggressive intervention significantly reduces the associated morbidity and mortality. Perivesical extravasate may be difficult to distinguish from adjacent or nearby bladder activity on scintiscan. Clarification of actual bladder contour and determination of its exact location within the pelvis may resolve such uncertainties. We describe imaging techniques that define the anatomic extent of the bladder and demonstrate our scintigraphic assessment of perivesical extravasation.
Subject(s)
Iodine Radioisotopes , Iodohippuric Acid , Kidney Transplantation , Pentetic Acid , Postoperative Complications/diagnostic imaging , Technetium , Urinary Bladder/diagnostic imaging , Urine , Adult , Child , Female , Humans , Male , Middle Aged , Radionuclide Imaging , Technetium Tc 99m PentetateSubject(s)
Hemangioma/diagnostic imaging , Indium , Radioisotopes , Skin Neoplasms/diagnostic imaging , Blood Platelets , Disseminated Intravascular Coagulation/diagnostic imaging , Disseminated Intravascular Coagulation/therapy , Hemangioma/therapy , Humans , Infant , Male , Radionuclide Imaging , Skin Neoplasms/therapy , SyndromeABSTRACT
A single patient who had a leukemic relapse six months after receiving a syngeneic bone marrow transplant was given "adoptive chemoimmunotherapy." Lymphocytes from the patients identical twin were alloactivated and grown in T cell growth factor in vitro. After receiving chemotherapy to reduce the number of relapsed leukemia cells, he received 1.1 X 10(10) in vitro alloactivated twin lymphocytes via intravenous and intraperitoneal injections. Although progressive Candidal pneumonia was fatal and prevented analysis of either efficacy or delayed toxicity of this potential form of therapy for this patient, radioactive 111In labelling and scanning showed dissemination of these lymphocytes following either injection route, with no clinical evidence of immediate toxicity.