ABSTRACT
In vitro modelling of neuronal pathologies is, in particular, demanding and a lot of efforts have been undertaken to differentiate skin derived precursor cells into neuronal cells. However, so far all attempts did not result in cells with functional features of neurons like the ability to generate action potentials or synaptic activity. Here, we report that simple modifications of the protocols result in neuronal cells that display action potentials and synaptic activity. We think that our observation is an important step to model individual neuronal pathologies in vitro.
ABSTRACT
A survey was conducted to evaluate nursing home referrals to consultant dietitians of residents with nutrition-related concerns, the frequency of such referrals, and the timeliness of dietitians' responses. The results showed that, although residents with significant weight loss and pressure ulcers constituted a higher proportion of nutrition concerns referred to the dietitian, most referrals were made from a week to a month after the nutrition concern was identified. Residents with tube feedings or dysphagia concerns were more likely to be referred in a more timely manner, within 1 to 2 days.
Subject(s)
Dietetics/statistics & numerical data , Nursing Homes , Patient Selection , Referral and Consultation/statistics & numerical data , Aged , Alaska , Dietetics/standards , Humans , Idaho , Oregon , Referral and Consultation/standards , Surveys and Questionnaires , Time Factors , WashingtonABSTRACT
An acute, febrile, self-limited disease process occurred in an otherwise healthy young adult that satisfies accepted criteria for the diagnosis of Kawasaki disease. Unusual features of this case include the patient's age and the documentation of notable, acute noncalculous distention of the gallbladder, a recognized complication of the condition. Evidence of cystic-duct obstruction during the acute phase of distention and subsequent establishment of patency during the convalescent stage is provided with the use of serial ultrasonographic and radioisotopic studies. Discussion of the possible mechanisms for acute hydrops of the gallbladder in Kawasaki disease is included and the need to consider this diagnosis in young adults with the appropriate clinical manifestations is underscored.
