ABSTRACT
Short gamma-ray bursts (GRBs) are associated with binary neutron star mergers, which are multimessenger astronomical events that have been observed both in gravitational waves and in the multiband electromagnetic spectrum1. Depending on the masses of the stars in the binary and on details of their largely unknown equation of state, a dynamically evolving and short-lived neutron star may be formed after the merger, existing for approximately 10-300 ms before collapsing to a black hole2,3. Numerical relativity simulations across different groups consistently show broad power spectral features in the 1-5-kHz range in the post-merger gravitational-wave signal4-14, which is inaccessible by current gravitational-wave detectors but could be seen by future third-generation ground-based detectors in the next decade15-17. This implies the possibility of quasiperiodic modulation of the emitted gamma rays in a subset of events in which a neutron star is formed shortly before the final collapse to a black hole18-21. Here we present two such signals identified in the short bursts GRB 910711 and GRB 931101B from archival Burst and Transient Source Experiment (BATSE) data, which are compatible with the predictions from numerical relativity.
ABSTRACT
OBJECTIVES: This study aimed to evaluate care gaps in risk- and harm-reduction strategies for patients prescribed opioids and to describe the implementation of a community pharmacy-based, pilot pain-management program. SETTING: The pilot program was established in a community pharmacy within an academic medical center. Patients enrolled were prescribed opioids for chronic pain by a rheumatology clinic. PRACTICE DESCRIPTION: The patients enrolled met 1 or more of the following criteria: they were prescribed more than 1 short-acting opioid; more than 90 morphine milligram equivalents/d; and more than 7 days' supply of medications for acute pain, including high-risk medication combinations. Comprehensive pain-medication assessments and pharmacist interventions were communicated to providers and implemented at follow-up. Data were analyzed using descriptive statistics. PRACTICE INNOVATION: A gap analysis was conducted by including 23 patients seen at the clinic over a 22-month period. The care gaps identified served as the basis for the pilot-program design. EVALUATION: Patients referred to the program were seen over a span of 1 to 2 visits; a total of 19 visits were documented. Pharmacists identified unaddressed issues with mood (68%). Recommendations made to the providers included additional adjuvant therapy (84%), dose adjustment (58%), and laboratory tests (74%). Naloxone was provided (58%), and education on naloxone use was provided at every visit. DISCUSSION: Untreated depression, anxiety, and insomnia were the most common problems identified by pharmacists. Pharmacists implemented and documented risk-reduction strategies and coprescribed naloxone more frequently compared with clinic providers. The program enhanced the pharmacists' ability to make safe and clinically appropriate decisions with regard to filling opioid prescriptions. CONCLUSION: The pilot program identified care gaps and provided an approach for engaging with patients and providers to optimize pain management, implement opioid risk-reduction strategies, and expand naloxone access.
