1.
Drug Des Deliv
; 3(2): 171-83, 1988 Jul.
Article
in English
| MEDLINE
| ID: mdl-3255328
ABSTRACT
Molecular orbital calculations and 13C and 15N NMR experiments have been performed on the O-methyl oximes of two types of 2-acyl cyclic 1,3-diones. One (III; X = CH2) was based on cyclohexane, and the other (X = O) on pyran. The data indicate that both the cyclohexane and pyran compounds prefer to exist as the oxime, rather than the enamine isomer. Two equivalent, interconverting, keto-enol tautomers exist in the cyclohexane compound. The pyran compound exists as the lactone-enol tautomer. Our results have implications in the design of herbicidal compounds and drugs containing similar tautomeric systems.
Subject(s)
Cyclohexanes/chemical synthesis , Cyclohexanones/chemical synthesis , Herbicides/analysis , Pyrans/chemical synthesis , Pyrones/chemical synthesis , Isomerism , Magnetic Resonance Spectroscopy , Models, Chemical
2.
J Am Chem Soc
; 95(20): 6861-3, 1973 Oct 03.
Article
in English
| MEDLINE
| ID: mdl-4746284
Subject(s)
Isoquinolines , Oxidation-Reduction , Benzyl Compounds , Fluoroacetates , Papaverine , Vanadium
3.
J Am Chem Soc
; 95(12): 4062-4, 1973 Jun 13.
Article
in English
| MEDLINE
| ID: mdl-4710068
4.
J Am Chem Soc
; 95(9): 2995-3000, 1973 May 02.
Article
in English
| MEDLINE
| ID: mdl-4694718
5.
J Org Chem
; 38(10): 1846-52, 1973 May 18.
Article
in English
| MEDLINE
| ID: mdl-4698926
6.
J Org Chem
; 38(1): 151-3, 1973 Jan 12.
Article
in English
| MEDLINE
| ID: mdl-4682659