1.
Transplant Proc
; 37(6): 2632-3, 2005.
Article
in English
| MEDLINE
| ID: mdl-16182769
ABSTRACT
We report herein on two male liver transplant (LT) recipients who presented with cyclosporine (CsA)-related gynecomastia 6 and 10 months after transplantation. The clinical workup showed increased luteinizing hormone (LH), associated with a slight reduction in testosterone blood levels in one patient and increased prolactin levels in the other. After excluding concomitant primary endocrine and/or malignant disease, conversion to tacrolimus (TAC) was performed resulting in clinical improvement of gynecomastia and return of hormone blood levels to normal range within 3 months. Our report confirms a putative role of CsA in post-LT gynecomastia, reversible however upon conversion to TAC.
Subject(s)
Cyclosporine/adverse effects , Gynecomastia/chemically induced , Liver Transplantation/immunology , Tacrolimus/therapeutic use , Carcinoma, Hepatocellular/surgery , Cholangitis, Sclerosing/surgery , Humans , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/therapeutic use , Liver Neoplasms/surgery , Luteinizing Hormone/blood , Male , Middle Aged , Postoperative Complications/etiology , Prolactin/blood , Testosterone/blood
2.
Biotechniques
; 28(1): 64-5, 2000 Jan.
Article
in English
| MEDLINE
| ID: mdl-10649772