1.
Analyst
; 126(3): 288-90, 2001 Mar.
Article
in English
| MEDLINE
| ID: mdl-11284327
ABSTRACT
The first hyphenation of high performance liquid chromatography (HPLC), electrochemical online oxidation and mass spectrometry (MS) is described. Ferrocenecarboxylic acid esters of various alcohols and phenols have been synthesized, separated by reversed-phase HPLC and oxidized (ionized) coulometrically prior to single quadrupole MS analysis using electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) interfaces. The dependence of the ionization on the electrochemical pretreatment is demonstrated. Limits of detection for selected derivatives range from 4 x 10(-9) to 4 x 10(-7) mol dm-3 depending on the individual compound and the selected interface.