Risk factors for corneal ulcers: a population-based matched case-control study in Nepal.

BACKGROUND/AIMS: We aimed to examine risk factors for corneal ulcer in a rural and peri-urban setting in Nepal. METHODS: This population-based matched case-control study was nested in a cluster randomised trial in 24 village development committees in Nepal. Incidence density sampling was used to match incident corneal opacity cases to controls, matching on time of opacity, age, sex and location. Cases and controls were invited to participate in a survey of risk factors for corneal ulcer. Risk factors were evaluated using conditional logistic regression to account for matching. RESULTS: Of the 540 participants with incident opacities identified in the trial, 433 were willing to participate in this substudy and matched to a control. Compared with controls, cases had lower odds of having any education vs no education (adjusted OR, aOR 0.60, 95% CI 0.39 to 0.94), working in non-manual labour occupations vs manual labour occupations (aOR 0.64, 95% CI 0.42 to 0.95) and preferring medical shops for ocular trauma versus eye care system centres (aOR 0.58, 95% CI 0.37 to 0.92). Cases had higher odds of protective goggle use versus no protection (aOR 3.8, 95% CI 1.3 to 11.0) and having an ocular injury vs none (aOR 7.7, 95% CI 4.3 to 13.6) compared with controls. CONCLUSION: We found ocular injury, manual labour and lower education to be strongly associated with the development of corneal ulcer. Given the persistent burden of corneal blindness in this area, prevention efforts could target efforts to increase access to care in areas where these factors are common.

Clinical Characteristics of Patients with Glaucoma Presenting to Bharatpur Eye Hospital: An Observational Study.

INTRODUCTION: Glaucoma is the second leading cause of blindness worldwide. Glaucoma will affect 79.6 million individuals by 2020, according to projections. Improved glaucoma screening and treatment approaches are urgently needed. The purpose of this study is to determine the clinical characteristics of glaucoma patients who visit Bharatpur Eye Hospital and aims to calculate the number of new diagnoses of glaucoma from 01 February 2020 to 15 March 2020. MATERIALS AND METHODS: This is a hospital-based, cross-section study. All patients with a diagnosis of glaucoma were invited to participate. The examination findings, diagnosis, and management were all documented. A standardized questionnaire was used to collect patient knowledge and understanding of glaucoma. RESULTS: Among 127 patients 52.8% were newly diagnosed with glaucoma. Many patients (59.8%) were symptomatic for more than 6 months. The mean presenting intraocular pressure was 20.86 mm Hg with an SD of 11.55 mm Hg. Only 44.9% of the participants had heard about glaucoma. Many participants (65.4%) did not have knowledge of glaucoma. Among 127 participants 9.4% had a family history of glaucoma. CONCLUSION: Glaucoma is a significant burden that presents challenges to ophthalmic services in Chitwan. Many people have a poor understanding of their condition and have limited access to services. There is a need to build a treatment infrastructure and raise public awareness.