[Pathogenetic aspects of hemolysis and changes of blood rheology in hereditary hemochromatosis]. / Patogeneticheskie aspekty gemoliza i izmenenii reologicheskikh svoistv krovi pri nasledstvennom gemokhromatoze.

AIM: To establish changes of and correlations between erythrodieresis and blood rheology in hereditary hemochromatosis (HHC). MATERIALS AND METHODS: Hemorheologic indices (asymptomatic blood and plasma viscosity, that of blood at low shift speed, red cell deformity and aggregation) were studied in 42 HHC patients and 23 healthy donors. The patients were divided into groups by homozygous (groups 1 and 2) or heterozygous (groups 3 and 4) allel genes and sex (females-groups 2 and 4, males-groups 1 and 3). RESULTS: All the patients had increased resistance of red cells in high percentage of their high-resistance populations (correlation index 0.8-0.9) due to destruction and elimination from the circulation. These changes were more pronounced in males, similar in homo- and heterozygotes. The presence in the peripheral blood of red cells with high resistance is associated with a 25-30% decrease in the red cell rigidity, in groups 1 and 3 this decrease reached 30-40%. To a certain degree high deformity and aggregation of red cells is explained by high plasma viscosity (correlation index 0.4). Plasma viscosity was high in all the patients of all groups. CONCLUSION: HHC runs with rejuvenascence of erythroid cells. Changed activity of erythrodieresis and damage to red cells at the level of microcirculation may be involved in iron metabolism disturbance and development of tissue hemosiderosis.

[Blood rheologic disorders in patients with polycythemia vera and their correction by therapeutic erythrocytapheresis]. / Gemoreologicheskie narusheniia u bol'nykh istinnoi politsitemii i ikh korrektsiia lechebnym éritrotsitaferezom.

The rheologic blood properties were studied in patients with polycythemia vera (PV) before and after erythrocytapheresis. The patients with PV showed a complex of hemorheologic disorders (high blood viscosity at different rates of deviation, intensified red blood cell aggregation, decreased deformability of these cells) found to be implicated in the disease pathogenesis. Erythrocytapheresis promoted the improvement of the rheologic characteristics such as dynamic blood viscosity and the red blood cell aggregation ratio.

[Hemorheologic disorders in shock of diverse etiology]. / Gemoreologicheskie narusheniia pri shoke razlichnoi étiologii.

Comparative investigation of rats has been conducted to study rheologic blood properties during relative compensation and decompensation of the hemorrhagic, traumatic and burning shock. The most obvious hemorheologic disturbances have been revealed during a burning shock and feebly marked-during a hemorrhagic shock.

[Effectiveness of plasmapheresis on the PF-0.5 blood separator in patients with paraproteinemic hemoblastoses]. / Effektivnost' plazmafereza na fraktsionatore PF-0,5 u bol'nykh paraproteinemicheskimi gemoblastozami.

Plasmapheresis on a Soviet-made PF-0.5 blood cell separator was performed in 20 PPH patients (altogether 33 sessions of plasmapheresis). 1600 to 3300 ml of plasma were removed during one session. Rheopolyglucin was mainly used as plasma-substituting liquid. The procedure was well tolerated by all the patients. After plasmapheresis biochemical indices were within normal. In multiple myeloma paraprotein was decreased by 42%. Waldenström's macroglobulinemia by 47%. Plasma viscosity was decreased 1.2- and 2-fold, respectively. The investigations showed a high efficacy and reliability of plasmapheresis with the help of the Soviet-made PF-0.5.

[Hematopoiesis in rats with destroyed posterior hypothalamic nuclei using the absolute number of bone marrow cells as an index]. / Gemopoéz u krys s razrushennymi iadrami zadnego otdela gipotalamussa po pokazateliam absoliutnogo chisla kletok kostnogo mozga.

The effect of bilateral electrocoagulation of mammilary body nuclei on the total count of bone marrow cells was studied in experiments on rats. The destruction of hypothalamus posterior nuclei resulted in erythropoiesis inhibition. A decrease in the mitotic number and in the erythroid cell total count was accompanied by granulocytopoiesis stimulation. There was a rise in the proliferative activity and in the total count of immature granulocytes in bone marrow of the rats.