ABSTRACT
BackgroundCOVID-19 outbreak poses an unprecedented challenge for societies, healthcare organizations and economies. In the present analysis we coupled climate data with COVID-19 spread rates worldwide, and in a single country (USA). MethodsData of confirmed COVID-19 cases was derived from the COVID-19 Global Cases by the CSSE at Johns Hopkins University up to March 19, 2020. We assessed disease spread by two measures: replication rate (RR), the slope of the logarithmic curve of confirmed cases, and the rate of spread (RoS), the slope of the linear regression of the logarithmic curve. ResultsBased on predefined criteria, the mean COVID-19 RR was significantly lower in warm climate countries (0.12{+/-}0.02) compared with cold countries (0.24{+/-}0.01), (P<0.0001). Similarly, RoS was significantly lower in warm climate countries 0.12{+/-}0.02 vs. 0.25 {+/-} 0.01 than in cold climate countries (P<0.001). In all countries (independent of climate classification) both RR and RoS displayed a moderate negative correlation with temperature R= -0.69, 95% confidence interval [CI], -0.87 to -0.36; P<0.001 and R= -0.72, 95% confidence interval [CI], -0.87 to -0.36; P<0.001, respectively. We identified a similar moderate negative correlation with the dew point temperature. Additional climate variables did not display a significant correlation with neither RR nor RoS. Finally, in an ancillary analysis, COVID-19 intra-country model using an inter-state analysis of the USA did not identify yet correlation between climate parameters and RR or RoS as of March, 19, 2020. ConclusionsOur analysis suggests a plausible negative correlation between warmer climate and COVID-19 spread rate as defined by RR and RoS worldwide. This initial correlation should be interpreted cautiously and be further validated over time, the pandemic is at different stages in various countries as well as in regions within these countries. As such, some associations may be more affected by local transmission patterns rather than by climate. Importantly, we provide an online surveillance dashboard (https://covid19.net.technion.ac.il/) to further assess the association between climate parameters and outbreak dynamics worldwide as time goes by. Research in contextO_ST_ABSEvidence before this studyC_ST_ABSThe coronavirus, COVID-19 pandemic caused by the novel SARS-CoV 2, challenges healthcare organizations and economies worldwide. There have been previous reports describing the association between seasonal climactic variance and SARS-CoV 1 as well as the MERS infections, but the association with SARS-CoV 2 and climate has not been described extensively. Added value of this studyOur analysis demonstrates a plausible negative correlation between warmer climate and COVID-19 spread rate as defined by RR and RoS worldwide in all countries with local transmission as of March 9, 2020. This initial correlation should be interpreted cautiously and be further validated over time. Importantly, we provide an online surveillance dashboard available at (https://covid19.net.technion.ac.il/) for further dynamic tracking of climate effect on COVID-19 disease spread rate worldwide and on intra-country analysis between USA states. Implications of all the available evidenceOur findings of decreased replication and spread rates of COVID-19 in warm climates may suggest that the inevitable seasonal variance will alter the dynamic of the disease spread in both hemispheres in the coming months. However, we warrant a cautious interpretation of these findings given the fact that we are in the initial steps of this outbreak in many "warm" climate countries, the high variance of the data and the dynamic changes in the disease surveillance and the lack of correlation based on the limited data in the US. We hope that the online tool coupling COVID-19 data with climate data will assist in tracking the disease and tailoring the needed measures to contain it.
