17q21 loci gene and childhood asthma / 国际儿科学杂志

Asthma,a chronic inflammatory airway disease,is influenced by both genetic and environmental factors.It is a complex disease that involves the interplay among multiple physiological processes.Currently,it has been identified that 17q21 loci genes especially orosomucoid like 3 (ORMDL3) and gasdermin B (GSMDB) are strongly linked with the susceptibility and severity of childhood asthma by using of the Genome-Wide Association Study (GWAS).Furthermore,a better understanding of the molecular mechanism contributes to the asthma target therapeutics and precision medicine.This review summarizes the 17q21 loci genes associated with the susceptibility,severity,and race specificities of childhood asthma.

The research progress of the relationship between vitamin A and asthma / 国际儿科学杂志

Vitamin A deficiency is a risk factor for asthma.Vitamin A plays important roles in maintaining airway epithelium phenotype,suppressing airway hyperresponsiveness,inducing immune tolerance and regulating airway inflammation,etc.The value of Vitamin A in asthma prevention and treatment has received wild attention but is still controverial.Vitamin A receptors are wildly expressed and the mechanisms are complex,more studies are needed to further clarify the relationship between Vitamin A and asthma.Besides,asthma is a polygenetic disease caused by environmental and genetic factors,and the current clinical studies of Vitamin A for prevention and treatment of asthma are not consistent.New epidemiologic studies about Vitamin A and asthma should take environmental and genetic factors into consideration.This article gives an overview about the research progress of the relationship between Vitamin A and asthma.

The mRNA expression and clinical significance of ORMDL3 gene in the peripheral blood of recurrent wheeze children / 中华实用儿科临床杂志

Objective To study the mRNA expression levels and clinical significance of omsomucoid 1-like protein 3 (ORMDL3) gene in the peripheral blood of recurrent wheeze children under 3 years old.Methods Peripheral blood specimens of 25 recurrent wheeze children including 14 non-atopy patients (group A) and 11 atopy patients (group B) that were registered in the First Affiliated Hospital of Nanjing Medical University,from Sep.2010 to Sep.2012 were enrolled based on the inclusion criteria and 24 non-allergic controls(the children with food allergy,drug allergy or ectema was excepted).The mRNA expression levels of ORMDL3 gene were detected by reverse transcription (RT)-PCR and clinical features were analyzed.Results The expression levels of ORMDL3 were up-regulated in the peripheral blood specimens of group B compared with group A (t =14.12,P ＜ 0.01).Compared with peripheral blood specimens from normal subjects,mRNA expression of ORMDL3 were significantly increased in recurrent wheeze children(t =10.29,5.73,P ＜0.01).The incidence of wheeze groups exist gender differences,male ＞ female.Wheeze usually with a high incidence in winter and spring.Conclusions The increase of ORMDL3 gene expression levels were correlated with recurrent wheeze under 3 years old especially in atopy group and may be involved in the pathogenesis of recurrent wheeze.