Therapeutic options for treating advanced colorectal cancer.

Despite recent decreases in overall incidence and mortality, colorectal cancer is a major health concern affecting 1 of every 18 Americans. Although potentially curable if detected early, 25% of patients present with metastatic disease, whereas another 10%-60% develop metastases resulting from the spread of microscopic disease not noted at the time of initial surgery. Historical treatment options for advanced colorectal cancer have been unsatisfactory, with survival rates of approximately 9%. This article reviews the newer treatment options that are available to patients while providing nurses with information they need to confidently care for patients receiving these treatments.