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The discovery and development of marine compounds with pharmaceutical potential.
Munro, M H; Blunt, J W; Dumdei, E J; Hickford, S J; Lill, R E; Li, S; Battershill, C N; Duckworth, A R.
J Biotechnol ; 70(1-3): 15-25, 1999 Apr 30.
Article in English | MEDLINE | ID: mdl-10412202

ABSTRACT

An assessment of the current status of marine anticancer compounds is presented along with a case study on the aquaculture of Lissodendoryx n. sp. 1, a sponge that produces the antimitotic agents halichondrin B and isohomohalichondrin B. The use of polymer therapeutics to enhance the properties of marine natural products is considered.


Subject(s)
Antineoplastic Agents/isolation & purification , Drug Design , Ethers, Cyclic/isolation & purification , Porifera/chemistry , Animals , Antineoplastic Agents/pharmacology , Aquaculture , Drug Screening Assays, Antitumor , Ethers, Cyclic/pharmacology , Humans , Macrolides , Porifera/metabolism
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