Controllable, Self-Powered, and High-Performance Short-Wavelength Infrared Photodetector Driven by Coupled Flexoelectricity and Strain Effect.

Mechanical deformation-induced strain gradients and coupled spontaneous electric polarization field in centrosymmetric materials, known as the flexoelectric effect, can generate ubiquitous mechanoelectrical functionalities, like the flexo-photovoltaic effect. Concurrently, nano/micrometer-scale inhomogeneous strain reengineers the electronic arrangements and in turn, could alter the fundamental limits of optoelectronic performance. Here, the flexoelectric effect-driven self-powered giant short-wavelength infrared (λ ≤ 1800 nm) photoresponse from centrosymmetric bulk silicon, indeed far beyond the fundamental bandgap (λ = 1100 nm) is demonstrated. Particularly, large on/off ratio (≈105 ), extremely high sensitivity (2.5 × 108 %), good responsivity of 96 mA W-1 , decent specific detectivity of ≈1.54 × 1014 Jones, and a rapid response speed of ≈100 µs, even at nanoscale (<30 nm), are measured at λ = 1620 nm. The infrared response sensitivity is tuned in a wide range (up to 1.4 × 108 %) by controlling the applied pointed force from 1 to 10 µN. These results confirm that emerging mechanoelectrical coupling not only sheds to achieve tunable optoelectronic performance beyond the fundamental limit, but also offers innovative numerous applications like mechanoptical switch, photovoltaic, sensors, and self-driving vehicles.

Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic.

Mannitol has recently been reported to be effective in enhancing the antinociceptive efficacy of lidocaine. No single study to date, however, has compared diphenhydramine with and without mannitol for nociceptive processing as an alternative local anesthetic. In this study, we examined the antinociceptive efficacy enhancements of diphenhydramine when combined with mannitol. Male Sprague-Dawley rats weighing 230-260 g were used in a hot plate test to evaluate the antinociceptive effects of diphenhydramine. All chemicals were dissolved in isotonic normal saline and administered subcutaneously into the plantar surface of the right hind paw at 10 min before the hot plate test. A subcutaneous injection of 0.5% or 1% diphenhydramine produced significant inhibition of the withdrawal latency time compared with the vehicle treatment. Antinociceptive effects appeared 10 min after the diphenhydramine injections and persisted for over 30 min. The antinociceptive effects of 1% diphenhydramine were not statistically different from those of 1% lidocaine. Although a subcutaneous injection of a 0.5 M mannitol solution alone did not affect the withdrawal latency time, 1% diphenhydramine with 0.5 M mannitol significantly enhanced antinociception. A subcutaneous injection of 1% diphenhydramine with epinephrine (1 : 100,000) solution did not increase the antinociceptive effect of the diphenhydramine. These results suggest that diphenhydramine with mannitol can be used as an alternative local anesthetic.

Environment-Adaptable Photonic-Electronic-Coupled Neuromorphic Angular Visual System.

Environment-adaptable photonic-electronic-coupled devices can help overcome major challenges related to the extraction of highly specific angular information, such as human visual perception. However, a true implementation of such a device has rarely been investigated thus far. Herein, we provide an approach and demonstrate a proof-of-concept solid-state semiconductor-based highly transparent, optical-electrical-coupled, self-adaptive angular visual perception system that can fulfill the versatile criteria of the human vision system. Specifically, all of the primitive functions of visual perception, such as broad angular sensing, processing, and manifold memory storage, are demonstrated and comodulated using optical and electric pulses. This development represents an essential step forward in the fabrication of an environment-adaptable artificial angular perception framework with deep implications in the fields of optoelectronics, artificial eyes, and memory storage applications.