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FEBS Lett ; 582(15): 2188-94, 2008 Jun 25.
Article in English | MEDLINE | ID: mdl-18486611

ABSTRACT

Type 2 diabetes mellitus (DM) and Alzheimer's disease (AD) share epidemiological and biochemical features. Both are characterized by insoluble protein aggregates with a fibrillar conformation--amylin in Type 2 DM pancreatic islets, and Abeta in AD brain. To determine whether amylin shares neurotoxic properties with Abeta, we incubated hippocampal and cortical neurons with Abeta42 and human amylin. Different from non-amyloidogenic rat amylin, both caused a dose-, time- and cell type-specific neurotoxicity supporting the notion of a similar toxic mechanism. Depending on the cell type, this finding is also supported by co-incubation of human amylin and Abeta.


Subject(s)
Amyloid beta-Peptides/toxicity , Amyloid/toxicity , Neurons/drug effects , Peptide Fragments/toxicity , Amino Acid Sequence , Animals , Cells, Cultured , Cerebral Cortex/cytology , Cerebral Cortex/drug effects , Hippocampus/cytology , Hippocampus/drug effects , Humans , Islet Amyloid Polypeptide , Molecular Sequence Data , Rats
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