ABSTRACT
Diabetes mellitus is one of the most common chronic degenerative diseases, and it is estimated to increase worldwide to around 415 million and to impact 642 million in 2040. Research shows that some plants are sources of bioactive compounds against diabetes. Thus, the objective of this work was to evaluate the oral toxicity and the hypoglycemic effect of the aqueous extract of the leaves of Cnidoscolus quercifolius Pohl. Diabetes was induced in Swiss mice with streptozotocin and the mice were treated with an aqueous extract of C. quercifolius leaves for a period of 30 days. Phytochemical analysis showed that the extract was rich in flavonoids, catechins and triterpenoid, which did not show any mortality and behavioral alterations in mice treated with 200, 1000, and 2000 mg/kg body weight of the extract for 14 days. Histopathological analysis of organs (kidney, pancreas, liver) from mice treated with the 2000 mg/kg extract revealed no architectural change. In the present study, we found a 29% reduction in glucose levels in animals receiving 200 mg/kg body weight. These results are very promising because they showed that C. quercifolius had a hypoglycemic effect and did not present oral toxicity, thus being a new source of compounds for the control of diabetes.
Subject(s)
Diabetes Mellitus, Experimental/drug therapy , Euphorbiaceae/chemistry , Hypoglycemic Agents/therapeutic use , Plant Extracts/therapeutic use , Animals , Female , Hypoglycemic Agents/toxicity , Kidney/drug effects , Lethal Dose 50 , Liver/drug effects , Male , Mice , Pancreas/drug effects , Plant Extracts/toxicity , Streptozocin , Toxicity TestsABSTRACT
A single-crystal of peptide L-alanyl-L-alanine (C6H12N2O3) was studied by Raman spectroscopy at low-temperature, and a tentative assignment of the normal modes was given. Evidence of a second order structural phase transition was found through Raman spectroscopy between the temperatures of 80K and 60K. Group theory considerations suggest that the transition leads the sample from the tetragonal to a monoclinic structure. Additionally, our study suggests that the mechanism for the structural phase transition is governed by the occupation of non-equivalent C1 local symmetry sites by the CH3 molecular groups. Analysis based on group theory suggests L-alanyl-L-alanine presents C2 symmetry at low temperatures.
Subject(s)
Dipeptides/chemistry , Spectrum Analysis, Raman/methods , Cold Temperature , Crystallization , Models, Molecular , Phase TransitionSubject(s)
Cystoscopes , Urethra , Urinary Catheterization/instrumentation , Female , Humans , Male , Radiography , Urethra/diagnostic imagingABSTRACT
Setenta e seis casos de prostatectomia com uso profilatico de heparina subcutanea em doses reduzidas sao apresentados e analisados. As complicacoes tromboembolicas praticamente inexistiram comparadas com o grupo controle
Subject(s)
Middle Aged , Humans , Male , Heparin , Prostatectomy , ThrombophlebitisABSTRACT
Um caso de fistula nefroapendico cutanea e apresentado, salientando-se sua raridade quando o processo e primariamente renal
Subject(s)
Adolescent , Humans , Female , Intestinal Fistula , Urinary FistulaABSTRACT
Os autores apresentam 14 casos de torcao espermaticos, diagnosticados e tratados, com a idade oscilando desde os RN ao adulto, ressaltando dados semioticos importantes para o diagnostico diferencial, enfatizando os cuidados com o testiculo contralateral, ressaltam a importancia de um diagnostico precoce e acurado que permitem uma resolucao satisfatoria, evitando a necrose e comentam as complicacoes
