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1.
Rev Esp Med Nucl ; 22(4): 244-9, 2003.
Article in Spanish | MEDLINE | ID: mdl-12846949

ABSTRACT

A method based upon the application of mathematical techniques of deconvolution on the classical compartmental model for the quantitative study of liver function from hepatobiliary scintigraphy using 99mTc-mebrofenin data is proposed. The theory in which the method is based upon is presented and a comparison with a published methodology of obtaining the hepatic extraction after scintigraphic sudies has been performed using the results on 36 rats studies obtained with the two methods. A highly significant correlation between the two techniques was verified. The characteristics of the two methodologies, the proposed one based upon a theoretical approach and the other one on an empirical approximation are discussed. Comments are made on the interest and limitations of the presented technique that may be an useful tool for the evaluation of hepatic insufficiency.


Subject(s)
Biliary Tract/diagnostic imaging , Imino Acids , Liver/diagnostic imaging , Organotechnetium Compounds , Radiopharmaceuticals , Aniline Compounds , Animals , Bile/metabolism , Biliary Tract/physiopathology , Cholestasis/diagnostic imaging , Glycine , Hepatocytes/metabolism , Imino Acids/pharmacokinetics , Ligation , Liver/physiopathology , Liver Function Tests , Male , Models, Biological , Organotechnetium Compounds/pharmacokinetics , Radionuclide Imaging , Radiopharmaceuticals/pharmacokinetics , Rats , Rats, Sprague-Dawley
2.
Rev. esp. med. nucl. (Ed. impr.) ; 22(4): 244-249, jul. 2003.
Article in Es | IBECS | ID: ibc-27438

ABSTRACT

Se propone un método basado en la aplicación de técnicas matemáticas de deconvolución sobre el modelo compartimental clásico para el estudio cuantitativo de la función hepática con datos de gammagrafía hepatobiliar con 99mTc-mebrofenina. Se presenta la teoría sobre la cual se basa el método y se hace una comparación con una metodología publicada para la obtención de la extracción hepática después de hacer estudios grammagráficos utilizando los resultados de 36 estudios en ratas, obtenidos con los dos métodos. Se comprobó una correlación altamente significativa entre las dos técnicas. Se discuten las características de las dos metodologías, la propuesta basada en un enfoque teórico y la otra en un enfoque empírico. Se comenta el interés y limitaciones de la técnica presentada que puede ser una herramienta útil para la evaluación de la insuficiencia hepática. (AU)


Subject(s)
Rats , Animals , Male , Organotechnetium Compounds , Rats, Sprague-Dawley , Radiopharmaceuticals , Models, Biological , Hepatocytes , Biliary Tract , Bile , Cholestasis , Liver , Ligation , Imino Acids , Liver Function Tests
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