Weight Gain from Birth to Adolescence and TyG Index at Age 18 Years: A Cohort Study in Northeast Brazil.

BACKGROUND: Developmental models suggest that the phenotypes may arise from an immediate or mediated adaptive metabolic response of the perinatal growth. Evidence on the cumulative effects of growth and factors associated with risk of insulin resistance in adolescents is lacking. OBJECTIVE: To investigate the association between birthweight, weight gain during infancy, childhood and adolescence and the triglyceride-glucose index in adolescents. METHODS: This is a cohort of 217 children born at term, followed for the first six months, and reassessed at 8 and 18 years of age. The variables of interest were birthweight, postnatal growth defined as rapid postnatal growth when the weight gain from birth to six months of age was greater than 0.67 z-score, and the same criterion was used for high BMI gain from ages 6 months to 8 years, and from 8 to 18 years. Socioeconomic condition, nutritional status, practice of physical exercises and consumption of ultra-processed foods were verified. Multivariate linear regression analysis was used to verify the effect of the variables on the triglyceride-glucose index. RESULTS: Birthweight was not associated with triglyceride-glucose index in adolescence. Rapid postnatal growth during the first 6 months, higher BMI gain from 8 to 18 years and higher waist circumference contributed significantly to explain higher triglyceride-glucose index. CONCLUSION FOR PRACTICE: Our findings suggest that rapid postnatal growth may be one of the first signs of a higher triglyceride-glucose index in adolescence and that attention should be paid to the greater gain in body mass between childhood and adolescence for the risk of a higher triglyceride-glucose index.

L-glutamine supplementation reduced morphological damage in the renal glomerulus of rats with Walker-256 tumor.

PURPOSE: To evaluate the effects of the experimental subcutaneous Walker-256 tumor and L-glutamine supplementation, an antioxidant, on the glomerular morphology of rats. METHODS: Twenty Wistar rats were distributed into four groups (n = 5): control (C); control treated with 2% L-glutamine (CG); rats with Walker-256 tumor (WT); and rats with Walker-256 tumor treated with 2% L-glutamine (WTG). Renal histological samples were submitted to periodic acid-Schiff and Masson's Trichrome staining to analyze glomerular density, morphometry of glomerular components and glomerulosclerosis; and to immunohistochemistry for fibroblast growth factor-2 (FGF-2). RESULTS: WT showed 50% reduction in body mass gain and cachexia index > 10%, while WTG demonstrated reduction in cachexia (p < 0.05). WT revealed reduction of glomerular density, increase in the glomerular tuft area, mesangial area, matrix in the glomerular tuft, decrease in the urinary space and synechia, and consequently higher glomerulosclerosis (p < 0.05). L-glutamine supplementation in the WTG improved glomerular density, and reduced glomerular tuft area, urinary space, mesangial area, and glomerulosclerosis compared to WT(p < 0.05). WT showed higher collagen area and FGF-2 expression compared to C (p < 0.05). WTG presented lower collagen fibers and FGF-2 expression compared to WT (p < 0.05). CONCLUSIONS: L-glutamine supplementation reduced cachexia and was beneficial for glomerular morphology of the rats, as well as it reduced kidney damage and improved the remaining glomeruli morphology.

Determining factors of child linear growth from the viewpoint of Bronfenbrenner's Bioecological Theory

Abstract Objective To analyze the factors associated with children's linear growth, according to the different subsystems of the 6Cs model and Bronfenbrenner's Bioecological Theory. Data sources Narrative review, carried out in the Scielo, Lilacs, Pubmed, and Science Direct databases, based on research using the terms Bioecological Theory, child growth, and risk factors, combined with the use of Boolean operators. Summary of findings According to the 6Cs model, proposed based on Bronfenbrenner's Bioecological Theory, the determining factors of children's linear growth are in six interrelated subsystems - cell, child, clan, community, country/state and culture. The empirical studies included in this review made it possible to analyze protection and risk factors within the subsystems. Among the protective factors: are adequate birth weight and satisfactory weight gain, breastfeeding for six months or more; proper hygienic habit of hand washing, proper elimination of feces, and access to clean water. As risk factors: low, birth weight and size, prematurity, multiple deliveries, short interval between deliveries, non-exclusive breastfeeding until the 3rd month, frequency and severity of infectious processes and anemia, little parental education, short maternal statur, inadequate maternal nutritional status, domestic violence, family poverty, food, and nutritional insecurity, living in rural areas or at high altitudes. Conclusion Children's linear growth is determined by interrelated factors that encompass aspects prior to the child's birth, as well as socioeconomic, political, family and community issues.

Birthweight, postnatal growth and blood pressure in adolescents of low socioeconomic condition: a cohort study in Northeast Brazil.

OBJECTIVE: To verify the influence of low birth weight and rapid postnatal weight gain and associated factors on blood pressure in adolescence in a population of low socioeconomic status, considering that injuries occur in the perinatal period can be predictors of future metabolic changes and are still poorly explored. METHODS: A cohort study was carried out with 208 adolescents, 78 born with low weight and 130 born with appropriate weight. The infants were followed up during the first six postnatal months and reassessed at 8 and 18 years of age. The independent variables were birthweight and postnatal weight gain. Rapid postnatal weight gain was defined when above 0.67 z score. The co-variables were sex, maternal height and family income at birth, nutritional status at eight years old, socioeconomic conditions, nutritional status, fat mass index, and physical activity level at 18 years. The outcome variable was blood pressure at 18 years old. The bivariate and multivariable logistic regression analysis were realized and p < 0,05 was considered significant. RESULTS: The proportion of adolescents with elevated blood pressure was 37.5%. The multivariable logistic regression analysis showed the variables independently associated with a higher chance of elevated blood pressure in adolescence were rapid postnatal weight gain (OR = 2.74; 95% CI 1.22-6.14; p = 0.014), male sex (OR = 4.15; 95% CI 1.66-10.38; p = 0.002) and being physically active (OR = 2.70; 95% CI 1.08-6.74; p = 0.034). CONCLUSIONS: The rapid postnatal weight gain was a predictor for elevated blood pressure in adolescence, independently of other factors.

Determining factors of child linear growth from the viewpoint of Bronfenbrenner's Bioecological Theory.

OBJECTIVE: To analyze the factors associated with children's linear growth, according to the different subsystems of the 6Cs model and Bronfenbrenner's Bioecological Theory. DATA SOURCES: Narrative review, carried out in the Scielo, Lilacs, Pubmed, and Science Direct databases, based on research using the terms Bioecological Theory, child growth, and risk factors, combined with the use of Boolean operators. SUMMARY OF FINDINGS: According to the 6Cs model, proposed based on Bronfenbrenner's Bioecological Theory, the determining factors of children's linear growth are in six interrelated subsystems - cell, child, clan, community, country/state and culture. The empirical studies included in this review made it possible to analyze protection and risk factors within the subsystems. Among the protective factors: are adequate birth weight and satisfactory weight gain, breastfeeding for six months or more; proper hygienic habit of hand washing, proper elimination of feces, and access to clean water. As risk factors: low, birth weight and size, prematurity, multiple deliveries, short interval between deliveries, non-exclusive breastfeeding until the 3rd month, frequency and severity of infectious processes and anemia, little parental education, short maternal statur, inadequate maternal nutritional status, domestic violence, family poverty, food, and nutritional insecurity, living in rural areas or at high altitudes. CONCLUSION: Children's linear growth is determined by interrelated factors that encompass aspects prior to the child's birth, as well as socioeconomic, political, family and community issues.

L-glutamine supplementation reduced morphological damage in the renal glomerulus of rats with Walker-256 tumor

ABSTRACT Purpose: To evaluate the effects of the experimental subcutaneous Walker-256 tumor and L-glutamine supplementation, an antioxidant, on the glomerular morphology of rats. Methods: Twenty Wistar rats were distributed into four groups (n = 5): control (C); control treated with 2% L-glutamine (CG); rats with Walker-256 tumor (WT); and rats with Walker-256 tumor treated with 2% L-glutamine (WTG). Renal histological samples were submitted to periodic acid-Schiff and Masson's Trichrome staining to analyze glomerular density, morphometry of glomerular components and glomerulosclerosis; and to immunohistochemistry for fibroblast growth factor-2 (FGF-2). Results: WT showed 50% reduction in body mass gain and cachexia index > 10%, while WTG demonstrated reduction in cachexia (p < 0.05). WT revealed reduction of glomerular density, increase in the glomerular tuft area, mesangial area, matrix in the glomerular tuft, decrease in the urinary space and synechia, and consequently higher glomerulosclerosis (p < 0.05). L-glutamine supplementation in the WTG improved glomerular density, and reduced glomerular tuft area, urinary space, mesangial area, and glomerulosclerosis compared to WT(p < 0.05). WT showed higher collagen area and FGF-2 expression compared to C (p < 0.05). WTG presented lower collagen fibers and FGF-2 expression compared to WT (p < 0.05). Conclusions: L-glutamine supplementation reduced cachexia and was beneficial for glomerular morphology of the rats, as well as it reduced kidney damage and improved the remaining glomeruli morphology.

Birthweight, postnatal growth and blood pressure in adolescents of low socioeconomic condition: a cohort study in Northeast Brazil

Abstract Objective To verify the influence of low birth weight and rapid postnatal weight gain and associated factors on blood pressure in adolescence in a population of low socioeconomic status, considering that injuries occur in the perinatal period can be predictors of future metabolic changes and are still poorly explored. Methods A cohort study was carried out with 208 adolescents, 78 born with low weight and 130 born with appropriate weight. The infants were followed up during the first six postnatal months and reassessed at 8 and 18 years of age. The independent variables were birthweight and postnatal weight gain. Rapid postnatal weight gain was defined when above 0.67 z score. The co-variables were sex, maternal height and family income at birth, nutritional status at eight years old, socioeconomic conditions, nutritional status, fat mass index, and physical activity level at 18 years. The outcome variable was blood pressure at 18 years old. The bivariate and multivariable logistic regression analysis were realized and p < 0,05 was considered significant. Results The proportion of adolescents with elevated blood pressure was 37.5%. The multivariable logistic regression analysis showed the variables independently associated with a higher chance of elevated blood pressure in adolescence were rapid postnatal weight gain (OR = 2.74; 95% CI 1.22-6.14; p= 0.014), male sex (OR = 4.15; 95% CI 1.66-10.38; p= 0.002) and being physically active (OR = 2.70; 95% CI 1.08-6.74; p= 0.034). Conclusions The rapid postnatal weight gain was a predictor for elevated blood pressure in adolescence, independently of other factors.

Combined use of systemic quercetin, glutamine and alpha-tocopherol attenuates myocardial fibrosis in diabetic rats.

This study aimed to analyze the effects of the quercetin (100 mg/kg), 1% glutamine and 1% α-tocopherol antioxidants in the myocardium of rats with streptozotocin-induced diabetes mellitus. Twenty male rats were subdivided into four groups (n = 5): N (normoglycemic); D (diabetic); NT (normoglycemic treated with antioxidants); and DT (diabetic treated with antioxidants) treated for 60 days. Clinical parameters, oxidative stress markers, inflammatory cytokines, myocardial collagen fibers and immunoexpression of superoxide dismutase 1 (SOD-1), glutathione peroxidase-1 (GPx-1), interleukin-1ß (IL-1-ß), transforming growth factor-beta (TGF-ß), and fibroblast growth factor-2 (FGF-2) were evaluated. Results showed reduced body weight, hyperphagia, polydipsia and hyperglycemic state in groups D and DT. The levels of glutathione (GSH) were higher in NT and DT compared to N (p < 0.01) and D (p < 0.001) groups, respectively. Greater GSH levels were found in DT when compared to N animals (p < 0.001). In DT, there was an increase in IL-10 in relation to N, D and NT (p < 0.05), while GPx-1 expression was similar to N and lower compared to D (p < 0.001). TGF-ß expression in DT was greater than N (p < 0.001) group, whereas FGF-2 in DT was higher than in the other groups (p < 0.001). A significant reduction in collagen fibers (type I) was found in DT compared to D (p < 0.05). The associated administration of quercetin, glutamine and α-tocopherol increased the levels of circulating interleukin-10 (IL-10) and GSH, and reduced the number of type I collagen fibers. Combined use of systemic quercetin, glutamine and alpha-tocopherol attenuates myocardial fibrosis in diabetic rats.

Salutogenesis, nutritional status and eating behaviour: a systematic review.

OBJECTIVE: To assess the relationship between the sense of coherence (SOC), eating behaviour and nutritional status. DESIGN: It is a systematic review. SETTING: The following databases were searched: MEDLINE/PubMed, Science Direct/Elsevier, LILACS/Bireme, SciELO and Google Scholar, using the indexed terms 'salutogenesis', 'sense of coherence', 'nutritional status', 'nutrition', 'eating behavior' and 'healthy eating'. The indexed terms were used in Portuguese and English according to the database searched. The data were extracted in a standardised way and the quality of the studies was assessed using the Newcastle-Ottawa Scale. PARTICIPANTS: Observational studies were included, with no limitations on the date of publication or language. RESULTS: After reading the titles and abstracts of 1855 articles, 107 full texts were retrieved, of which 27 were included. Of these, twenty-five were cross-sectional and two were longitudinal. The average score for Newcastle-Ottawa studies was 6 and most studies were rated as moderate and low quality. The cumulative sample size of all included studies was 28 981 adults and the elderly, aged between 18 and 81 years. The studies were carried out in fifteen different countries. Fifteen articles assessed eating behaviour/habit and twelve assessed nutritional status. Studies have shown that SOC has a positive relationship with an appropriate eating behaviour/habit. On the other hand, the relationship between SOC and nutritional status was controversial among studies. The heterogeneity of the data resulting from the use of different methods of evaluation of the outcomes of interest (nutritional status and eating behaviour) made it impossible to perform a meta-analysis. CONCLUSION: SOC was positively associated with adequate eating behaviour. However, it was not possible to establish a relationship between SOC and nutritional status.

Oral Health Care of Children and Adolescents with Different Impairments of Cerebral Palsy: Barriers and Challenges

Abstract Objective: To evaluate the barriers to access and oral health care faced by children and adolescents with Cerebral Palsy (CP) according to their motor impairment through the perception of caregivers. Material and Methods: A case series study was carried out at three health institutions in Pernambuco, Brazil. The study sample consisted of 94 caregivers of 5-to-18-year-old patients with CP, according to GMFCS (The Gross Motor Function Classification System). Data were collected using a semi-structured form to evaluate the barriers to access and analyzed statistically by the chi-square and Fisher exact tests, adopting a 5% level of significance. In addition, binary logistic regression was performed to determine the weight of the variables in explaining the outcome variable. Results: There were major difficulties involving transportation (p=0.04) and structural accessibility to dental services (p<0.01) among children and adolescents with severe CP. In addition, the more severe the CP, the greater the difficulty of accessibility (OR=4.09,) and the lower the income (OR=8.80), the greater the motor impairment. Conclusion: Despite the availability of access to dental services, low-income families have more severe CP patients, contributing to the daily difficulties already faced by them in oral health care.

Situação de insegurança alimentar em domicílios de Pernambuco, Região Nordeste do Brasil: contribuições para discussão da violação do direito à alimentação / Food insecurity in households in Pernambuco, Northeast region of Brazil: contributions to the discussion on the violation of the right to adequate food

Resumo O objetivo deste estudo foi investigar os fatores associados à insegurança alimentar em domicílios do Estado de Pernambuco, localizado na região Nordeste do Brasil. Trata-se de um estudo transversal realizado em 1.008 domicílios particulares. Para a investigação, utilizou-se a Escala Brasileira de Insegurança Alimentar (EBIA) e foram analisadas associações com variáveis socioeconômicas, demográficas e práticas relacionadas à alimentação. Calculou-se razão de prevalência e ajuste por meio da regressão de Poisson, sendo estatisticamente significantes aquelas associações cujo p≤0,05. Encontrou-se prevalência de 68,4% de insegurança alimentar. Apresentaram associação com insegurança: escolaridade do chefe da família; renda per capita; participação no programa Bolsa Família; número de moradores; regime de ocupação do domicílio; classe social; práticas; e opiniões acerca da alimentação da família. O maior risco de insegurança foi encontrado naqueles com pior condição econômica, em beneficiários do Bolsa Família e naqueles que indicavam a falta de produtos ultraprocessados para melhorar a alimentação da família. Observou-se insegurança alimentar atrelada às condições de vulnerabilidade social e àqueles que não consideravam ter uma boa alimentação. Grande parte dos sujeitos referiram utilizar os recursos do Bolsa Família para aquisição de alimentos, o que reforça a importância dessa estratégia na promoção do acesso à alimentação.

Abstract This study aimed to investigate factors associated with food insecurity in households in the state of Pernambuco, in the Northeast region of Brazil. This is a cross-sectional study carried out in 1,008 private households. The investigation used the Brazilian Food Insecurity Scale (EBIA) and analyzed associations with socioeconomic and demographic variables, as well as practices related to eating. Prevalence ratio and adjustment were calculated using Poisson regression, and associations where p ≤ 0.05 were statistically significant. Food insecurity prevalence was 68.4%. Variables associated with insecurity were: education of the head of the family; per capita income; participation in the Bolsa Família Program; number of residents; occupation of the household; social class; practices and opinions about family eating habits. The greatest insecurity risk was found in those with the worst economic conditions, in beneficiaries of the Bolsa Família Program and in those who considered the lack of ultra-processed products to improve the family's diet. Food insecurity was linked to conditions of social vulnerability and to those who did not perceive that they had a good diet. Most of the subjects reported using resources of the Bolsa Família program to purchase food, which reinforces the importance of this strategy in promoting access to food.

Educational material on intermittent urethral catheterization in children: a scoping review / Materiales educativos sobre cateterismo uretral intermitente en niños: revisión de alcance / Materiais educativos no cateterismo uretral intermitente em crianças: revisão de escopo

ABSTRACT Objective to analyze diverse scientific evidence about educational materials related to intermittent urethral catheterization in children. Method a scoping review based on the method proposed by the Joana Briggs Institute and conducted in nine stages from July to December 2021, with the following guiding question: "Which is the available evidence about educational materials on intermittent urethral catheterization in children?". Articles from the following databases were analyzed: National Library of Medicine, Cumulative Index to Nursing and Allied Health Literature, Scientific Electronic Library Online and SciVerse Scopus. Results six of the 3,323 articles retrieved were kept after applying the eligibility criteria and excluding the duplicates. The publication dates varied from 2009 to 2019; five were published in Brazil and one in the United States. Regarding the design, one was a cross-sectional study and there were two descriptive studies, two methodological studies and one case study. The data were presented considering the following variables: type of material, means of dissemination, target audience, and theoretical framework of the educational materials. Conclusion the studies analyzed in this review presented several educational materials, such as elaboration of educational software, a Telenursing manual, an educational video to guide parents and an online forum. Therefore, these materials are useful as teaching and learning strategies for caregivers of children undergoing intermittent urethral catheterization.

RESUMEN Objetivo analizar diversas evidencias científicas sobre materiales educativos relacionados con cateterismo uretral intermitente en niños. Metodo revisão de alcance basada en el método propuesto por el Joana Briggs Institute y realizada en nueve etapas entre julio y diciembre de 2021, con la siguiente pregunta guía: "¿De qué evidencias se dispone acerca de materiales educativos sobre cateterismo uretral intermitente en niños?". Se analizaron artículos de las siguientes bases de datos: National Library of Medicine, Cumulative Index to Nursing and Allied Health Literature, Scientific Electronic Library Online y SciVerse Scopus. Resultados seis de los 3.323 artículos recuperados se mantuvieron después de aplicar los criterios de elegibilidad y de excluir los duplicados. Las fechas de publicación variaron entre los años 2009 y 2019; cinco se publicaron en Brasil y uno en Estados Unidos. En relación co el diseño, uno era un estudio transversal y había dos estudios descriptivos, dos estudios metodológicos y un estudio de caso. Los datos se presentaron sobre la base de las siguientes variables: tipo de material, vehiculo de diseminación, público objetivo y referencial teórico de los materiais educativos. Conclusión los estudios que se analizaron en esta revisión presentaron diversos materiales educativos, como ser la elaboración de un programa de software educativo, un manual de Tele-Enfermería, un video educativo para orientar a los padres y foro virtual. EN consecuencia, estos materiales sirven com estrategias de enseñanza y aprendizaje para cuidadores de niños sometidos a cateterismo uretral intermitente.

RESUMO Objetivo Analisar evidências científicas sobre materiais educativos relativos ao cateterismo uretral intermitente em crianças. Metodo Revisão de escopo, baseada no método proposto pelo Joana Briggs Institute, realizada em nove etapas, no período de julho a dezembro de 2021, com a pergunta norteadora: "Quais as evidências disponíveis acerca de materiais educativos sobre cateterismo uretral intermitente em crianças?". Analisaram-se artigos das bases de dados: National Library of Medicine's,Cumulative Index to Nursing and Allied Health Literature, Scientific Electronic Library Online e SciVerse Scopus. Resultados Dos 3.323 artigos recuperados, foram mantidos seis artigos após aplicação dos critérios de elegibilidade e exclusão dos duplicados. As datas de publicação variaram de 2009 a 2019; cinco foram publicados no Brasil e um nos Estados Unidos. Quanto ao desenho, um era estudo transversal, dois estudos descritivos, dois estudos metodológicos e um estudo de caso. Os dados foram apresentados com base nas variáveis: tipo de material, meio de disponibilização, público-alvo e referencial teórico dos materiais educativos. Conclusão Os estudos analisados nesta revisão apresentaram diversos materiais educativos, como a construção de software educativo, manual de tele-enfermagem, vídeo educativo para orientação de pais e fórum virtual. Estes materiais são, portanto, úteis como estratégias de ensino e aprendizagem para cuidadores de crianças em cateterismo uretral intermitente.

A new insight into the definition of microcephaly in Zika congenital syndrome era.

This study aimed to compare the anthropometric measurements and body proportionalities of neonates born before the Zika virus epidemic with those born during this period. We compared 958 neonates born during the pre-Zika epidemic with 264 neonates born during the epidemic period. The newborns had their head circumference, weight, and length classified according to the Fenton & Kim growth chart. We considered disproportionate those individuals that presented microcephaly and adequate weight or length for sex and gestational age, and those whose head circumferences were lower than the ratio ((length / 2) + 9.5) - 2.5cm. We estimated the frequencies of Zika positivity and brain imaging findings among neonates with microcephaly born during the epidemic period, concerning the anthropometric and body proportionality parameters. Low weight and proportionate microcephaly were similar among newborns from both periods. However, the frequencies of newborns with microcephaly with a very low length and disproportionate microcephaly were higher among the neonates of the epidemic period with brain abnormalities and positive for Zika virus. We conclude that, at birth, the disproportion between head circumference and length can be an indicator of the severity of microcephaly caused by congenital Zika.

Prevalence, Trends and Conditions for the DTP3 Vaccine: A 25-Year Historical Perspective.

BACKGROUND: The aim was to verify the prevalence of vaccination coverage, tendency and factors of the third dose of the vaccine against diphtheria, tetanus and pertussis-DTP3 in surveys over the period of 25 years in a state of the Northeast of Brazil. METHODS: Cross-sectional and temporal series, utilizing ad hoc database, were extracted from the Health and Nutrition State Research 1991, 1997, 2006 and 2015/2016. Children from 12 to 23 months of age with proof in the vaccination card were included. The vaccination coverage (outcome) of each year was calculated, the tendency throughout the period was analyzed and the associations through Pearson chi-squared were tested. The results of the first and last survey were compared with a significance level of 5%. The reasons of the crude prevalence and confidence intervals of 95% were estimated. RESULTS: The vaccination coverage in 1991, 1997, 2006 and 2015/2016 was 77.6%, 82.7%, 89.7% and 72.9%, respectively, with an increasing tendency from 1991 to 2006 (p<0.001) and decreasing between 2006 and 2015/2016 (p<0.001). Factors in 1991: low socioeconomic conditions; lack of access to health service and pre-natal care, nutritional deficit and diarrhea in children (p<0.005). In 2015/2016, low socioeconomic conditions and diarrhea persisted and a larger family size, black, negative self-perception of happiness, both from the mother (p<0.05), were identified. CONCLUSION: The factors of the recent decrease of vaccination coverage are complex, multifactorial, dependent of context and even on subjective aspects of the maternal perception. Its identification contributed to the understanding of inadequate vaccination at the state level.

Excess weight among women in a low-income urban community: socioeconomic, demographic and reproductive factors. / Excesso de peso em mulheres de uma comunidade urbana de baixa renda: fatores socioeconômicos, demográficos e reprodutivos.

The aim of the present study was to investigate the prevalence of excess weight and associated factors in women of reproductive age living in a low-income community. A cross-sectional study was conducted with a sample of 663 women 15 to 49 years of age residing in the neighborhood of Coelhos in the city of Recife, Brazil. Body mass index (BMI)-for-age was used to classify the nutritional status of the adolescents (15 to 19 years of age), adopting Z-score of ≥+1 for the definition of overweight. For the adults, BMI≥25.0 kg/m² was considered indicative of overweight. Socioeconomic, demographic and reproductive variables were analyzed as possible factors associated with overweight. The prevalence of excess weight was found in two thirds of the sample. The results of the Poisson multiple regression analysis showed a significantly higher prevalence of excess weight with the advance in age, among those with a younger menarche age, those who had three or more pregnancies, those living with their partner and those self-declared black or white. Multiparity was the only factor associated with excess weight that could be modified, which underscores the importance of prenatal and family planning services to its prevention and control.

O objetivo do estudo foi avaliar a prevalência de excesso de peso e fatores associados nas mulheres em idade reprodutiva, residentes em uma comunidade de baixa renda. Estudo transversal cuja amostra consistiu em 663 mulheres, na faixa etária de 15 a 49 anos, domiciliadas na comunidade dos Coelhos, Recife-PE. O IMC para idade foi utilizado para classificar o estado nutricional de mulheres entre 15 e 19 anos, considerando ≥+1 escore Z para definir excesso de peso. Nas mulheres com idade superior a 19 anos, considerou-se o IMC≥25,0 kg/m². Variáveis socioeconômicas, demográficas e reprodutivas foram analisadas como possíveis fatores associados ao excesso de peso. A prevalência do excesso de peso foi observada em dois terços das mulheres estudadas. Os resultados da análise de regressão múltipla de Poisson mostraram uma prevalência significantemente maior do excesso de peso em mulheres com o avançar da idade cronológica, com menor idade da menarca, que tiveram três ou mais gestações, que coabitavam com o companheiro e se autodenominaram com cor preta ou cor branca. A multiparidade foi o único fator associado ao excesso de peso passível de modificação, o que reforça a necessidade de destacar a importância dos serviços de pré-natal e planejamento familiar na sua prevenção e controle.

Neurodevelopment in Children Exposed to Zika Virus: What Are the Consequences for Children Who Do Not Present with Microcephaly at Birth?

The relation of Zika virus (ZIKV) with microcephaly is well established. However, knowledge is lacking on later developmental outcomes in children with evidence of maternal ZIKV infection during pregnancy born without microcephaly. The objective of this analysis is to investigate the impact of prenatal exposure to ZIKV on neuropsychomotor development in children without microcephaly. We evaluated 274 children including 235 ZIKV exposed and 39 controls using the Bayley-III Scales of Infant and Toddler Development (BSIDIII) and neurological examination. We observed a difference in cognition with a borderline p-value (p = 0.052): 9.4% of exposed children and none of the unexposed control group had mild to moderate delays. The prevalence of delays in the language and motor domains did not differ significantly between ZIKV-exposed and unexposed children (language: 12.3% versus 12.8%; motor: 4.7% versus 2.6%). Notably, neurological examination results were predictive of neurodevelopmental delays in the BSIDIII assessments for exposed children: 46.7% of children with abnormalities on clinical neurological examination presented with delay in contrast to 17.8% among exposed children without apparent neurological abnormalities (p = 0.001). Overall, our findings suggest that relative to their unexposed peers, ZIKV-exposed children without microcephaly are not at considerably increased risk of neurodevelopmental impairment in the first 42 months of life, although a small group of children demonstrated higher frequencies of cognitive delay. It is important to highlight that in the group of exposed children, an abnormal neuroclinical examination may be a predictor of developmental delay. The article contributes to practical guidance and advances our knowledge about congenital Zika.

Chemogenomics and bioinformatics approaches for prioritizing kinases as drug targets for neglected tropical diseases.

Neglected tropical diseases (NTDs) are a group of twenty-one diseases classified by the World Health Organization that prevail in regions with tropical and subtropical climate and affect more than one billion people. There is an urgent need to develop new and safer drugs for these diseases. Protein kinases are a potential class of targets for developing new drugs against NTDs, since they play crucial role in many biological processes, such as signaling pathways, regulating cellular communication, division, metabolism and death. Bioinformatics is a field that aims to organize large amounts of biological data as well as develop and use tools for understanding and analyze them in order to produce meaningful information in a biological manner. In combination with chemogenomics, which analyzes chemical-biological interactions to screen ligands against selected targets families, these approaches can be used to stablish a rational strategy for prioritizing new drug targets for NTDs. Here, we describe how bioinformatics and chemogenomics tools can help to identify protein kinases and their potential inhibitors for the development of new drugs for NTDs. We present a review of bioinformatics tools and techniques that can be used to define an organisms kinome for drug prioritization, drug and target repurposing, multi-quinase inhibition approachs and selectivity profiling. We also present some successful examples of the application of such approaches in recent case studies.

BIRTH WEIGHT AND OVERWEIGHT IN ADOLESCENTS: THE ERICA PROJECT IN THE CITY OF RECIFE, PERNAMBUCO.

OBJECTIVE: To verify the association of anthropometric parameters at birth, socioeconomic and biological variables, physical activity, and parental nutritional status with overweight and abdominal obesity in adolescents. METHODS: A cross-sectional study was carried out on 39 public and private schools in Recife (state of Pernambuco, Brazil). The sample consisted of 1,081 teenagers aged from 12 to 17 years. Data were collected from the Study of Cardiovascular Risks in Adolescents (ERICA). Body mass index according to age (BMI-for-age), waist circumference (WC), and waist-to-height ratio (WtHR) were considered as outcome variables, whereas the explanatory variables were birth weight, Röhrer's Ponderal Index (RPI), biological and socioeconomic variables, physical activity, and parental nutritional status. The crude and adjusted prevalence ratios (PR) for the studied association were estimated by Poisson Regression. RESULTS: The multivariate Poisson regression showed that the variable that remained significantly associated with overweight in adolescence was maternal overweight, PR=1.86 (95% confidence interval [95%CI] 1.09-3.17). High birth weight also remained significantly associated with abdominal obesity assessed by WC, PR=3.25 (95%CI 1.0-9.74). CONCLUSIONS: High birth weight may be a marker for abdominal obesity in adolescence; and high maternal BMI, for overweight.

Assistência qualificada a gestantes em uso de álcool e drogas / Qualified assistance to pregnant women with alcohol and drug abuse problems / Asistencia calificada a mujeres embarazadas en uso de alcohol y drogas

Objetivo: analisar a assistência de Enfermagem prestada às gestantes que fazem uso abusivo de álcool e outras drogas. Método: informa-se que participaram da pesquisa sete enfermeiras do Centro de Atenção Psicossocial para tratamento de usuários de álcool e outras drogas. Detalha-se que a coleta ocorreu por meio de entrevista semiestruturada, com a organização dos dados seguindo a técnica da Análise de Conteúdo, enquanto o estudo foi fundamentado na Teoria de Imogene King. Resultados: evidenciaram-se três temáticas: olhar direcionado ao alcance de redução de danos; a integralidade do ser; e processo de Enfermagem x integralização da assistência. Conclusão: conclui-se que, apesar de a assistência ser baseada na redução de danos, o estudo demonstrou que há uma falha no atendimento às gestantes usuárias de drogas, considerando que um dos princípios do Sistema Único de Saúde, a integralidade, ainda está longe de ser atendido, pois a gestante é assistida apenas acerca dos aspectos do uso de álcool e outras drogas.(AU)

Objective: to analyze the nursing assistance provided to pregnant women who abuse alcohol and other drugs. Method: seven nurses from the Center for Psychosocial Attention for the treatment of alcohol and other drug users are reported to have participated in the survey. The data collection was carried out by means of a semi-structured interview, with the data organization following the Content Analysis technique, while the study was based on Imogene King's Theory. Results: three themes were made evident: addressing the scope of harm reduction; the individual's integrality; and the nursing process x integralization of assistance. Conclusion: it is concluded that, although the assistance is based on harm reduction, the study showed that there is a failure in the assistance to pregnant drug users, considering that one of the principles of the National Health System, integrality, is still far from being accomplished, once the pregnant woman is only assisted regarding the aspects of the use of alcohol and other drugs.(AU)

Objetivo: analizar los cuidados de enfermería que se brindan a las gestantes que abusan del alcohol y otras drogas. Método: se informa que siete enfermeras del Centro de Atención Psicosocial participaron en la investigación para tratar a los usuarios de alcohol y otras drogas. Se detalla que la recolección se produjo a través de entrevistas semiestructuradas, con la organización de los datos siguiendo la técnica de Análisis de Contenido, mientras que el estudio se basó en la Teoría de Imogene King. Resultados: se evidenciaron tres temas: mirando hacia la reducción de daños; la integralidad del ser; y el proceso de enfermería x prestación de asistencia. Conclusión: se concluye que, si bien la asistencia se basa en la reducción de daños, el estudio demostró que existe una falla en la atención a las embarazadas que consumen drogas, considerando que uno de los principios del Sistema Único de Salud, la integralidad, aún está lejos lejos de ser atendido, ya que la mujer embarazada es asistida solo en aspectos del uso de alcohol y otras drogas.(AU)

Artificial Intelligence Applied to the Rapid Identification of New Antimalarial Candidates with Dual-Stage Activity.

Increasing reports of multidrug-resistant malaria parasites urge the discovery of new effective drugs with different chemical scaffolds. Protein kinases play a key role in many cellular processes such as signal transduction and cell division, making them interesting targets in many diseases. Protein kinase 7 (PK7) is an orphan kinase from the Plasmodium genus, essential for the sporogonic cycle of these parasites. Here, we applied a robust and integrative artificial intelligence-assisted virtual-screening (VS) approach using shape-based and machine learning models to identify new potential PK7 inhibitors with in vitro antiplasmodial activity. Eight virtual hits were experimentally evaluated, and compound LabMol-167 inhibited ookinete conversion of Plasmodium berghei and blood stages of Plasmodium falciparum at nanomolar concentrations with low cytotoxicity in mammalian cells. As PK7 does not have an essential role in the Plasmodium blood stage and our virtual screening strategy aimed for both PK7 and blood-stage inhibition, we conducted an in silico target fishing approach and propose that this compound might also inhibit P. falciparum PK5, acting as a possible dual-target inhibitor. Finally, docking studies of LabMol-167 with P. falciparum PK7 and PK5 proteins highlighted key interactions for further hit-to lead optimization.