Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Bioorg Med Chem Lett ; 14(17): 4399-403, 2004 Sep 06.
Article in English | MEDLINE | ID: mdl-15357961

ABSTRACT

New N-heteroarylcarbonylalanines of the D-series were stereoselectively prepared from enoates derived from D-mannitol. These compounds were active in binding and functional assays of the NMDA sub-type of glutamate receptors. A pyridine derivative inhibited MK801 binding, protected neurons from excitotoxic damage and blocked NMDA-induced currents in neurons. A thiophene derivative positively modulated the NMDA receptor, possibly through the allosteric glycine site.


Subject(s)
Alanine/chemical synthesis , Alanine/metabolism , Receptors, N-Methyl-D-Aspartate/metabolism , Animals , Cerebral Cortex/metabolism , Dizocilpine Maleate/metabolism , Drug Evaluation, Preclinical/methods , Ligands , Protein Binding/physiology , Rats , Rats, Wistar , Stereoisomerism , Thiophenes/chemical synthesis , Thiophenes/metabolism
SELECTION OF CITATIONS
SEARCH DETAIL
...