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Bioorg Med Chem Lett
; 14(17): 4399-403, 2004 Sep 06.
Article
in English
| MEDLINE
| ID: mdl-15357961
ABSTRACT
New N-heteroarylcarbonylalanines of the D-series were stereoselectively prepared from enoates derived from D-mannitol. These compounds were active in binding and functional assays of the NMDA sub-type of glutamate receptors. A pyridine derivative inhibited MK801 binding, protected neurons from excitotoxic damage and blocked NMDA-induced currents in neurons. A thiophene derivative positively modulated the NMDA receptor, possibly through the allosteric glycine site.