ABSTRACT
The inhibitor of growth 2 (ING2) is a member of lNG family, involved in cell cycle regulation, DNA repair, apoptosis and senescence, and participating in chromatin remodeling and transcriptional regulation by histone modification. Recent researches suggest ING2 plays roles in carcinogenesis both as tumor suppressor gene and ongocene depending on tumor types and cell status. Here, we investigated the status of ING2 in a series of 64 Chinese non-small cell lung cancer (NSCLC)patients using immunohistochemistry (IHC) and confirmed the results with Western blotting. RT-PCR results revealed the expression level of ING2 was consistent with mRNA level. The IHC results showed that ING2 protein expression was significantly decreased in NSCLC samples compared with normal lung tissues (PSubject(s)
Adenocarcinoma/genetics
, Biomarkers, Tumor/genetics
, Carcinoma, Non-Small-Cell Lung/genetics
, Carcinoma, Squamous Cell/genetics
, Homeodomain Proteins/genetics
, Lung Neoplasms/genetics
, Receptors, Cytoplasmic and Nuclear/genetics
, Tumor Suppressor Proteins/genetics
, Adenocarcinoma/metabolism
, Adenocarcinoma/secondary
, Aged
, Biomarkers, Tumor/metabolism
, Blotting, Western
, Carcinoma, Non-Small-Cell Lung/metabolism
, Carcinoma, Non-Small-Cell Lung/secondary
, Carcinoma, Squamous Cell/metabolism
, Carcinoma, Squamous Cell/secondary
, Female
, Follow-Up Studies
, Homeodomain Proteins/metabolism
, Humans
, Immunoenzyme Techniques
, Lung Neoplasms/metabolism
, Lung Neoplasms/pathology
, Lymphatic Metastasis
, Male
, Middle Aged
, Neoplasm Staging
, Prognosis
, RNA, Messenger/genetics
, Real-Time Polymerase Chain Reaction
, Receptors, Cytoplasmic and Nuclear/metabolism
, Reverse Transcriptase Polymerase Chain Reaction
, Tumor Suppressor Proteins/metabolism
