Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp.

The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 plays a pivotal role in the life cycle of the novel coronavirus and stands as a significant and promising target for anti-SARS-CoV-2 drugs. Non-nucleoside inhibitors (NNIs), as a category of compounds directed against SARS-CoV-2 RdRp, exhibit a unique and highly effective mechanism, effectively overcoming various factors contributing to drug resistance against nucleoside inhibitors (NIs). This review investigates various NNIs, including both natural and synthetic inhibitors, that closely interacting with the SARS-CoV-2 RdRp with valid evidences from in vitro and in silico studies.

Camellia oleifera Abel shells as a new biosorbent to remove methylene blue from aqueous solutions.

This study aimed at investigating the feasibility of using Camellia oleifera Abel shell (COAS), an agriculture product in middle-west region in China, for the adsorption of methylene blue (MB), a cationic dye. Batch adsorption experiments were carried out to evaluate the effects of contact time, pH, adsorbent dosage, temperature and initial concentration on the adsorption of MB. Adsorption equilibrium studies showed that MB adsorption followed Langmuir model with a maximum adsorption capacity of 454.54 mg/g. The results demonstrated that the COAS is a promising adsorbent in the removal of MB from aqueous solutions.